{ "_id": "6a4f735921b18e1548501fbe", "Package": "nmw", "Version": "0.3.1", "Date": "2026-06-09", "Title": "Understanding Nonlinear Mixed Effects Modeling for Population\nPharmacokinetics", "Description": "This shows how 'NONMEM' (Beal SL, Sheiner LB, Boeckmann\nAJ, Bauer RJ. NONMEM 7.5 Users Guides. Icon plc, 2020)\nsoftware works. 'NONMEM' classical estimation methods such as\n'First Order (FO) approximation', 'First Order Conditional\nEstimation (FOCE)', and 'Laplacian approximation' are\nexplained. Functions are also provided for post-run processing\nof NONMEM output files, generating PDF diagnostic reports\nincluding objective function value analysis, parameter\nestimates, prediction and residual diagnostics, empirical Bayes\nestimate (EBE) analysis, input data summary, and individual\npharmacokinetic parameter distributions. Helper utilities for\nbuilding NONMEM-ready datasets from SDTM-style source tables\nare also included.", "ByteCompile": "yes", "License": "GPL-3", "Copyright": "2017-, Kyun-Seop Bae", "Author": "Kyun-Seop Bae [aut, cre]", "Maintainer": "Kyun-Seop Bae ", "Authors@R": "person(given = \"Kyun-Seop\",\nfamily = \"Bae\",\nrole = c(\"aut\", \"cre\"),\nemail = \"k@acr.kr\")", "URL": "https://cran.r-project.org/package=nmw", "Contact": "Kyun-Seop Bae ", "Config/testthat/edition": "3", "Encoding": "UTF-8", "NeedsCompilation": "no", "RoxygenNote": "7.3.3", "Packaged": { "Date": "2026-07-09 10:06:21 UTC", "User": "root" }, "Repository": "https://cran.r-universe.dev", "Date/Publication": "2026-06-09 08:44:29 UTC", "RemoteUrl": "https://github.com/cran/nmw", "RemoteRef": "HEAD", "RemoteSha": "03210439395741b28202ff3d1c323d7ed26e3fdd", "_user": "cran", "_type": "src", "_file": "nmw_0.3.1.tar.gz", "_fileid": "https://r2.ropensci.org/d391eaef7cbc4de9e1f4e6705d6437e6521e7c2f1b41f0b1bc208348dce5466f", 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", "message": "version 0.3.1\n", "time": 1780994669 }, "_maintainer": { "name": "Kyun-Seop Bae", "email": "k@acr.kr" }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 3.5.0", "role": "Depends" }, { "package": "numDeriv", "role": "Depends" }, { "package": "MASS", "role": "Imports" }, { "package": "grDevices", "role": "Imports" }, { "package": "graphics", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "utils", "role": "Imports" }, { "package": "testthat", "version": ">= 3.0.0", "role": "Suggests" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2026-10", "n": 1 }, { "week": "2026-15", "n": 1 }, { "week": "2026-19", "n": 1 }, { "week": "2026-24", "n": 1 } ], "_tags": [ { "name": "0.1.6", "date": "2026-03-08" }, { "name": "0.2.0", "date": "2026-04-07" }, { "name": "0.3.0", "date": "2026-05-08" }, { "name": "0.3.1", "date": "2026-06-09" } ], "_stars": 1, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "followers": 617, "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 459, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/nmw" }, "_searchresults": 9, "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/NEWS.html", "extra/NEWS.txt", "extra/nmw.html", "manual.pdf" ], "_realowner": "cran", "_cranurl": false, "_releases": [ { "version": "0.1.1", "date": "2017-03-14" }, { "version": "0.1.2", "date": "2017-10-20" }, { "version": "0.1.4", "date": "2018-04-10" }, { "version": "0.1.5", "date": "2023-05-10" }, { "version": "0.1.6", "date": "2026-03-08" }, { "version": "0.2.0", "date": "2026-04-07" }, { "version": "0.3.0", "date": "2026-05-08" }, { "version": "0.3.1", "date": "2026-06-09" } ], "_exports": [ "add_crcl_cg", "AddCox", "AddDoNoTaLD", "AddPage", "BtwTagMat", "BtwTagVals", "build_dose_records", "build_nm_dataset", "build_obs_records", "CalcSmat", "ClosePDF", "code_race", "code_sex", "CombDmExPc", "CovStep", "crcl_cg", "dat2_time_to_posix", "DECN", "DesclVar", "DxPlotPost", "EBEpair", "EstStep", "ExpandDoseHist", "GetAICc", "GetCountEps", "GetCountEta", "GetCountObs", "GetCountPara", "GetEstMethod", "GetOFV", "InitStep", "locf_value", "LogDV", "LogDV2", "ltv2mat", "mat2ltv", "mat2utv", "merge_cov_locf", "MinSuccess", "mlr2", "Mx", "nm_to_molar", "NMIDStat", "NMVarStat", "nmw_report_ebe", "nmw_report_indipk", "nmw_report_input", "nmw_report_ofv", "nmw_report_output", "nmw_report_param", "nmw_report_pred", "nmw_report_resid", "nmw_run", "Obj", "ObjEta", "Oi", "Oi0", "Oi1", "OiS0", "OiS1", "Outline", "parse_dtc", "ParseOut", "PostHocEta", "PrepPDF", "PrinMTxt", "PrinTxt", "RemoveNA", "ResTest", "run.test.nm", "ScaleVar", "SESuccess", "SqrtInvCov", "SumOut", "TabStep", "TrimOut", "utv2mat" ], "_help": [ { "page": "nmw-package", "title": "Understanding Nonlinear Mixed Effects Modeling for Population Pharmacokinetics", "topics": [ "nmw-package", "nmw" ] }, { "page": "add_crcl_cg", "title": "Add CRCL Column via Cockcroft-Gault", "topics": [ "add_crcl_cg" ] }, { "page": "AddCox", "title": "Add a Covariate Column to an Existing NONMEM dataset", "topics": [ "AddCox" ] }, { "page": "AddDoNoTaLD", "title": "Add Dose Number, Time of Latest Dose, and Time after Latest Dose", "topics": [ "AddDoNoTaLD" ] }, { "page": "AddPage", "title": "Add a New Page to PDF", "topics": [ "AddPage" ] }, { "page": "BtwTagMat", "title": "Extract Matrix from NONMEM XML Output", "topics": [ "BtwTagMat" ] }, { "page": "BtwTagVals", "title": "Extract Vector of Values Between XML Tags", "topics": [ "BtwTagVals" ] }, { "page": "build_dose_records", "title": "Build NONMEM Dose Records", "topics": [ "build_dose_records" ] }, { "page": "build_nm_dataset", "title": "Build a NONMEM-Format Dataset from DM/EX/PC", "topics": [ "build_nm_dataset" ] }, { "page": "build_obs_records", "title": "Build NONMEM Observation Records", "topics": [ "build_obs_records" ] }, { "page": "ClosePDF", "title": "Close PDF Output", "topics": [ "ClosePDF" ] }, { "page": "code_race", "title": "Code RACE as Integer", "topics": [ "code_race" ] }, { "page": "code_sex", "title": "Code SEX as Integer", "topics": [ "code_sex" ] }, { "page": "CombDmExPc", "title": "Combine the demographics(DM), dosing(EX), and DV(PC) tables into a new NONMEM dataset", "topics": [ "CombDmExPc" ] }, { "page": "CovStep", "title": "Covariance Step", "topics": [ "CovStep" ] }, { "page": "crcl_cg", "title": "Cockcroft-Gault Creatinine Clearance", "topics": [ "crcl_cg" ] }, { "page": "dat2_time_to_posix", "title": "Combine Date and Time Strings into POSIXct", "topics": [ "dat2_time_to_posix" ] }, { "page": "DxPlotPost", "title": "Diagnostic Plot for Post-Processing", "topics": [ "DxPlotPost" ] }, { "page": "EBEpair", "title": "EBE Pair Plot", "topics": [ "EBEpair" ] }, { "page": "EstStep", "title": "Estimation Step", "topics": [ "EstStep" ] }, { "page": "ExpandDoseHist", "title": "Expand Dose History with ADDL/II Records", "topics": [ "ExpandDoseHist" ] }, { "page": "GetAICc", "title": "Get Corrected AIC (AICc)", "topics": [ "GetAICc" ] }, { "page": "GetCountEps", "title": "Get Count of Epsilons", "topics": [ "GetCountEps" ] }, { "page": "GetCountEta", "title": "Get Count of Etas", "topics": [ "GetCountEta" ] }, { "page": "GetCountObs", "title": "Get Count of Observations", "topics": [ "GetCountObs" ] }, { "page": "GetCountPara", "title": "Get Count of Parameters", "topics": [ "GetCountPara" ] }, { "page": "GetEstMethod", "title": "Get Estimation Method", "topics": [ "GetEstMethod" ] }, { "page": "GetOFV", "title": "Get Objective Function Value", "topics": [ "GetOFV" ] }, { "page": "InitStep", "title": "Initialization Step", "topics": [ "InitStep" ] }, { "page": "locf_value", "title": "LOCF / LOCB Lookup", "topics": [ "locf_value" ] }, { "page": "LogDV", "title": "Check if Model Uses Log-Transformed DV (from Control File)", "topics": [ "LogDV" ] }, { "page": "LogDV2", "title": "Check if Model Uses Log-Transformed DV (from FSUBS)", "topics": [ "LogDV2" ] }, { "page": "merge_cov_locf", "title": "Merge Time-Varying Covariates by LOCF", "topics": [ "merge_cov_locf" ] }, { "page": "MinSuccess", "title": "Check Minimization Success", "topics": [ "MinSuccess" ] }, { "page": "mlr2", "title": "Multiple Linear Regression with Influence Diagnostics", "topics": [ "mlr2" ] }, { "page": "nm_to_molar", "title": "Convert NM Dataset from Mass to Molar Units", "topics": [ "nm_to_molar" ] }, { "page": "NMIDStat", "title": "NONMEM Individual (ID) Statistics", "topics": [ "NMIDStat" ] }, { "page": "NMVarStat", "title": "NONMEM Variable Statistics", "topics": [ "NMVarStat" ] }, { "page": "nmw_report_ebe", "title": "Generate EBE Diagnostics Report (S5-EBE.PDF)", "topics": [ "nmw_report_ebe" ] }, { "page": "nmw_report_indipk", "title": "Generate Individual PK Parameter Report (SC-IndiPK.PDF)", "topics": [ "nmw_report_indipk" ] }, { "page": "nmw_report_input", "title": "Generate Input Data Summary Report (SA-Input.PDF)", "topics": [ "nmw_report_input" ] }, { "page": "nmw_report_ofv", "title": "Generate OFV Diagnostic Report (S1-OFV.PDF)", "topics": [ "nmw_report_ofv" ] }, { "page": "nmw_report_output", "title": "Generate NONMEM Output Report (SB-Output.PDF)", "topics": [ "nmw_report_output" ] }, { "page": "nmw_report_param", "title": "Generate Parameter Estimates Report (S2-Parameters.PDF)", "topics": [ "nmw_report_param" ] }, { "page": "nmw_report_pred", "title": "Generate Prediction Diagnostics Report (S3-Predictions.PDF)", "topics": [ "nmw_report_pred" ] }, { "page": "nmw_report_resid", "title": "Generate Residual Diagnostics Report (S4-Residuals.PDF)", "topics": [ "nmw_report_resid" ] }, { "page": "nmw_run", "title": "Run All NONMEM Post-Processing Reports", "topics": [ "nmw_run" ] }, { "page": "Outline", "title": "Draw Model Development Flow Diagram", "topics": [ "Outline" ] }, { "page": "parse_dtc", "title": "Parse SDTM-Style DTC Strings into POSIXct", "topics": [ "parse_dtc" ] }, { "page": "ParseOut", "title": "Parse Value After Tag from NONMEM Output", "topics": [ "ParseOut" ] }, { "page": "PrepPDF", "title": "Prepare PDF Output", "topics": [ "PrepPDF" ] }, { "page": "PrinMTxt", "title": "Print Multiple Lines of Text", "topics": [ "PrinMTxt" ] }, { "page": "PrinTxt", "title": "Print Text at Position", "topics": [ "PrinTxt" ] }, { "page": "RemoveNA", "title": "Remove Rows with NA Values", "topics": [ "RemoveNA" ] }, { "page": "ResTest", "title": "Residual Count Test Using Binomial Distribution", "topics": [ "ResTest" ] }, { "page": "run.test.nm", "title": "Runs Test for NONMEM Residuals", "topics": [ "run.test.nm" ] }, { "page": "SESuccess", "title": "Check Standard Error Success", "topics": [ "SESuccess" ] }, { "page": "SumOut", "title": "Summarize Multiple NONMEM Runs", "topics": [ "SumOut" ] }, { "page": "TabStep", "title": "Table Step", "topics": [ "TabStep" ] }, { "page": "TrimOut", "title": "Trimming and beautifying NONMEM original OUTPUT file", "topics": [ "TrimOut" ] } ], "_rundeps": [ "MASS", "numDeriv" ], "_score": 1.6020599913279625, "_indexed": true, "_nocasepkg": "nmw", "_universes": [ "cran" ], "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "0.3.1", "date": "2026-07-09T10:08:27.000Z", "distro": "resolute", "commit": "03210439395741b28202ff3d1c323d7ed26e3fdd", "fileid": "https://r2.ropensci.org/e8091dbe75249e3ec7e943c09de89d9f69d8121f3a5c7e5e6cdbbc849067cdf9", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/29010236504" }, { "r": "4.6.1", "os": "linux", "version": "0.3.1", "date": "2026-07-09T10:08:30.000Z", "distro": "resolute", "commit": "03210439395741b28202ff3d1c323d7ed26e3fdd", "fileid": "https://r2.ropensci.org/99e579d2f9e41800eb8923c0ca39b7ab2bdcfc1eb40bfaebdb4a8f69b801ae9c", "status": "success", "check": "OK", 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