{ "_id": "6ad535f143d630dc48a3fc5c", "Package": "multigrain", "Title": "Optimise Graphical Approaches to Multiple Testing Procedures", "Version": "1.0.0", "Authors@R": "c(\nperson(\"Alex\", \"Spiers\", , \"alex.d.spiers@gsk.com\", role = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0002-8874-085X\")),\nperson(\"Dragoș\", \"Moldovan-Grünfeld\", , \"dragos.v.moldovan-grunfeld@gsk.com\", role = \"aut\"),\nperson(\"GlaxoSmithKline Research & Development Limited\", role = c(\"cph\", \"fnd\"))\n)", "Description": "Find the optimal graphical multiple testing procedure for\nconfirmatory clinical trials that test several hypotheses\nacross endpoints, doses, or subpopulations. Choose the graph\nmaximising an explicit gain-function: a user-defined measure of\ntrial success that scores each possible set of rejected\nhypotheses. Given simulated p-values, search over hypothesis\nweights and transition weights to maximise expected trial\nsuccess. Conventional power criteria are recovered and the\nfamily-wise error rate is strongly controlled due to the search\nbeing confined to graphical procedures. Described in Spiers,\nGrayling, Wheeler, and Mander (2026) \"Gain-function\noptimisation of graphical multiple testing procedures for\nconfirmatory clinical trials\" .", "License": "LGPL (>= 3)", "URL": "https://github.com/GSK-Biostatistics/multigrain,\nhttps://gsk-biostatistics.github.io/multigrain/", "BugReports": "https://github.com/GSK-Biostatistics/multigrain/issues", "Config/Needs/website": "rmarkdown, gMCP, graphicalMCP, gridExtra", "Config/roxygen2/markdown": "TRUE", "Config/roxygen2/version": "8.1.0", "Config/testthat/edition": "3", "Config/testthat/parallel": "true", "Config/testthat/start-first": "optimisation*", "Encoding": "UTF-8", "Language": "en-GB", "LazyData": "true", "SystemRequirements": "GNU make", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-10-18 21:03:49 UTC", "User": "root" }, "Author": "Alex Spiers [aut, cre] (ORCID:\n), Dragoș\nMoldovan-Grünfeld [aut], GlaxoSmithKline Research & Development\nLimited [cph, fnd]", "Maintainer": "Alex Spiers ", "Config/pak/sysreqs": "make", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2026-10-18 16:20:14 UTC", "RemoteUrl": "https://github.com/cran/multigrain", "RemoteRef": "HEAD", "RemoteSha": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "_user": "cran", "_type": "src", "_file": "multigrain_1.0.0.tar.gz", "_fileid": "https://r2.ropensci.org/4c7535d4e1363612e70b289117e6fa1d2f106c4ad8911b9d5732399899441193", "_filesize": 539718, "_sha256": "4c7535d4e1363612e70b289117e6fa1d2f106c4ad8911b9d5732399899441193", "_expires": "2027-01-26T21:11:11.000Z", "_created": "2026-10-18T21:03:49.000Z", "_published": "2026-10-18T21:11:13.759Z", "_buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211", "_status": "success", "_host": "GitHub-Actions", "_jobs": [ { "job": 117789487528, "time": 189, "config": "linux-devel-arm64", "r": "4.7.0", "check": "OK", "artifact": "12151430118" }, { "job": 117789487393, "time": 245, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "12150877089" }, { "job": 117789487565, "time": 204, "config": "linux-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "12151116135" }, { "job": 117789487398, "time": 189, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "12150752500" }, { "job": 117788648761, "time": 215, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "12150244652" }, { "job": 117789487425, "time": 116, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "12150556902" }, { "job": 117789487373, "time": 376, "config": "windows-devel-arm64", "r": "4.7.0", "check": "OK", "artifact": "12151100772" }, { "job": 117789487452, "time": 312, "config": "windows-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "12151200458" }, { "job": 117789487372, "time": 391, "config": "windows-release-arm64", "r": "4.6.1", "check": "OK", "artifact": "12150981117" }, { "job": 117789487443, "time": 258, "config": "windows-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "12150553301" } ], "_upstream": "https://github.com/cran/multigrain", "_commit": { "id": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "author": "Alex Spiers ", "committer": "cran-robot ", "message": "version 1.0.0\n", "time": 1792340414 }, "_maintainer": { "name": "Alex Spiers", "email": "alex.d.spiers@gsk.com", "orcid": "0000-0002-8874-085X" }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.1.0", "role": "Depends" }, { "package": "Rcpp", "role": "LinkingTo" }, { "package": "RcppParallel", "role": "LinkingTo" }, { "package": "cli", "role": "Imports" }, { "package": "dplyr", "role": "Imports" }, { "package": "GA", "role": "Imports" }, { "package": "ggplot2", "role": "Imports" }, { "package": "ggraph", "role": "Imports" }, { "package": "glue", "role": "Imports" }, { "package": "igraph", "role": "Imports" }, { "package": "mvtnorm", "role": "Imports" }, { "package": "nloptr", "role": "Imports" }, { "package": "purrr", "role": "Imports" }, { "package": "Rcpp", "role": "Imports" }, { "package": "RcppParallel", "version": ">= 5.1.10", "role": "Imports" }, { "package": "rlang", "version": ">= 1.2.0", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "tibble", "role": "Imports" }, { "package": "tidyr", "role": "Imports" }, { "package": "utils", "role": "Imports" }, { "package": "vctrs", "role": "Imports" }, { "package": "withr", "role": "Imports" }, { "package": "gMCPLite", "role": "Suggests" }, { "package": "spelling", "role": "Suggests" }, { "package": "svglite", "role": "Suggests" }, { "package": "testthat", "version": ">= 3.0.0", "role": "Suggests" }, { "package": "vdiffr", "role": "Suggests" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2026-42", "n": 1 } ], "_tags": [ { "name": "1.0.0", "date": "2026-10-18" } ], "_stars": 0, "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "followers": 634, "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 0, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/multigrain" }, "_devurl": "https://github.com/gsk-biostatistics/multigrain", "_pkgdown": "https://gsk-biostatistics.github.io/multigrain/", "_searchresults": 9, "_topics": [ "cpp" ], "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/manual.pdf", "extra/multigrain.html", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md" ], "_cranurl": false, "_releases": [ { "version": "1.0.0", "date": "2026-10-18" } ], "_exports": [ "calc_ncp", "calc_power_pvals", "control_global", "control_local", "control_nsim_global", "control_nsim_local", "graph_constraint", "graph_constraint_free", "graph_optimal_get_control", "graph_optimise", "graph_optimize", "graph_random", "is_graph_valid", "multigrain_control", "multigrain_verbosity", "normalise_sum", "simulate_pvalues", "trial_success" ], "_datasets": [ { "name": "graph_optimal_example", "title": "Optimised graph example", "object": "graph_optimal_example", "class": [ "multigrain_graph_optimal" ], "fields": [], "table": false, "tojson": false } ], "_help": [ { "page": "graph_constraint_plot", "title": "Autoplot method for 'multigrain_graph_constraint' objects", "topics": [ "autoplot.multigrain_graph_constraint", "plot.multigrain_graph_constraint" ] }, { "page": "graph_optimal_plot", "title": "Autoplot method for 'multigrain_graph_optimal' objects", "topics": [ "autoplot.multigrain_graph_optimal", "plot.multigrain_graph_optimal" ] }, { "page": "calc_ncp", "title": "Calculate non-centrality parameter", "topics": [ "calc_ncp" ] }, { "page": "calc_power_pvals", "title": "Calculate power for a graph-based multiple test procedure using p-values", "topics": [ "calc_power_pvals" ] }, { "page": "control_global", "title": "Modify global optimisation options", "topics": [ "control_global" ] }, { "page": "control_local", "title": "Modify local optimisation options", "topics": [ "control_local" ] }, { "page": "control_nsim", "title": "Modify the number of simulations", "topics": [ "control_nsim_global", "control_nsim_local" ] }, { "page": "graph_constraint", "title": "Create a _graph constraint_ for optimisation procedures", "topics": [ "graph_constraint" ] }, { "page": "graph_constraint_free", "title": "Create an unconstrained _graph constraint_", "topics": [ "graph_constraint_free" ] }, { "page": "graph_optimal_example", "title": "Optimised graph example", "topics": [ "graph_optimal_example" ] }, { "page": "graph_optimal_get_control", "title": "Get the optimisation control", "topics": [ "graph_optimal_get_control" ] }, { "page": "graph_optimisation", "title": "Optimise graph-based multiple testing procedures", "topics": [ "graph_optimise", "graph_optimize" ] }, { "page": "graph_random", "title": "Generate random graph", "topics": [ "graph_random" ] }, { "page": "is_graph_valid", "title": "Check the validity of a graph-based MTP", "topics": [ "is_graph_valid" ] }, { "page": "multigrain_control", "title": "Set parameters for graph optimisation", "topics": [ "multigrain_control" ] }, { "page": "multigrain_verbosity", "title": "Multigrain verbosity", "topics": [ "multigrain_verbosity" ] }, { "page": "normalise_sum", "title": "Normalise graph weights to sum to a target value", "topics": [ "normalise_sum" ] }, { "page": "simulate_pvalues", "title": "Simulate raw p-values", "topics": [ "simulate_pvalues" ] }, { "page": "trial_success", "title": "Create a _trial success_ function", "topics": [ "trial_success" ] } ], "_readme": "https://github.com/cran/multigrain/raw/HEAD/README.md", "_rundeps": [ "base64enc", "cachem", "cli", "codetools", "cpp11", "crayon", "dplyr", "farver", "fastmap", "foreach", "GA", "generics", "ggforce", "ggplot2", "ggraph", "ggrepel", "glue", "graphlayouts", "gridExtra", "gtable", "igraph", "isoband", "iterators", "jsonlite", "labeling", "lattice", "lifecycle", "magrittr", "MASS", "Matrix", "memoise", "mvtnorm", "nloptr", "pillar", "pkgconfig", "polyclip", "purrr", "R6", "RColorBrewer", "Rcpp", "RcppArmadillo", "RcppParallel", "rlang", "S7", "scales", "stringi", "stringr", "systemfonts", "tibble", "tidygraph", "tidyr", "tidyselect", "tweenr", "utf8", "vctrs", "viridis", "viridisLite", "withr" ], "_sysdeps": [ { "shlib": "libstdc++", "package": "libstdc++6", "source": "gcc", "version": "16-20260322-1ubuntu1", "name": "c++", "homepage": "http://gcc.gnu.org/", "description": "GNU Standard C++ Library v3" } ], "_score": 1.6989700043360187, "_indexed": false, "_nocasepkg": "multigrain", "_universes": [ "cran", "gsk-biostatistics" ], "_indexurl": "https://gsk-biostatistics.r-universe.dev/multigrain", "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.0.0", "date": "2026-10-18T21:05:48.000Z", "distro": "resolute", "arch": "aarch64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/d25e27bd8f331b8a3c1a6d2293d497a6537c589f18c381ec045856f047ac2901", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.7.0", "os": "linux", "version": "1.0.0", "date": "2026-10-18T21:06:13.000Z", "distro": "resolute", "arch": "x86_64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/b1343cce1f0a48038965a4613bce3b4129d2c982056a580df5957f784bd6116b", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.6.1", "os": "linux", "version": "1.0.0", "date": "2026-10-18T21:05:59.000Z", "distro": "resolute", "arch": "aarch64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/34f6aea92f0fa1a3a13f174aa3d567b2fa7f4d76c62b6f3e5f03382d7891fabd", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.6.1", "os": "linux", "version": "1.0.0", "date": "2026-10-18T21:06:10.000Z", "distro": "resolute", "arch": "x86_64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/68fe50f01d09b2a7e0c80ab61fe4621eaa1d7234ea1740987e6c76993e8c9a1f", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.6.0", "os": "wasm", "version": "1.0.0", "date": "2026-10-18T21:06:05.000Z", "arch": "emscripten", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/4bd204d8d989389f1d70d85945733c2f92a6687592d888a0045db40bcac41c0c", "status": "success", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.7.0", "os": "win", "version": "1.0.0", "date": "2026-10-18T21:07:25.000Z", "arch": "aarch64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/d6afc9a974ae7bb7a00ab046741b83e3a24af861b0f66cb3d34758f8dbe7bf59", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.7.0", "os": "win", "version": "1.0.0", "date": "2026-10-18T21:05:26.000Z", "arch": "x86_64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/ab6e7cfb3734d7ae2767321090e8521e18b4614deae138369ece32c251aab52d", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.6.1", "os": "win", "version": "1.0.0", "date": "2026-10-18T21:07:32.000Z", "arch": "aarch64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/833fa009a54f9053de3cd8804f825c55896551a07b2e45661870a34db2755187", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" }, { "r": "4.6.1", "os": "win", "version": "1.0.0", "date": "2026-10-18T21:05:16.000Z", "arch": "x86_64", "commit": "2e7c6f94f917893fc32513823c86a79a09f97cd1", "fileid": "https://r2.ropensci.org/1630ae6ed84852473c156369e8186250abdadf71d7ffd15b477064f6d0193a73", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/39165866211" } ] }