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  "Description": "The rapid screening of effective and optimal therapies\nfrom large numbers of candidate combinations, as well as\nexploring subgroup efficacy, remains challenging, which\nnecessitates innovative, integrated, and efficient trial\ndesigns(Yuan, Y., et al. (2016) <doi:10.1002/sim.6971>).\nMIDAS-2 package enables quick and continuous screening of\npromising combination strategies and exploration of their\nsubgroup effects within a unified platform design framework. We\nused a regression model to characterize the efficacy pattern in\nsubgroups. Information borrowing was applied through Bayesian\nhierarchical model to improve trial efficiency considering the\nlimited sample size in subgroups(Cunanan, K. M., et al. (2019)\n<doi:10.1177/1740774518812779>). MIDAS-2 provides an adaptive\ndrug screening and subgroup exploring framework to accelerate\nimmunotherapy development in an efficient, accurate, and\nintegrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi:\n10.1177/1740774517692302>).",
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