{ "_id": "6a46c63ec3efdb0cb7aa46d2", "Package": "gsDesign2", "Title": "Group Sequential Design with Non-Constant Effect", "Version": "1.1.9", "Authors@R": "c(\nperson(\"Keaven\", \"Anderson\", email = \"keaven_anderson@merck.com\", role = c(\"aut\")),\nperson(\"Yujie\", \"Zhao\", email = \"yujie.zhao@merck.com\", role = c(\"aut\", \"cre\")),\nperson(\"Yilong\", \"Zhang\", email = \"elong0527@gmail.com\", role = c(\"aut\")),\nperson(\"John\", \"Blischak\", email = \"jdblischak@gmail.com\", role = c(\"aut\")),\nperson(\"Yihui\", \"Xie\", email = \"yihui.xie@merck.com\", role = c(\"aut\")),\nperson(\"Nan\", \"Xiao\", email = \"nan.xiao1@merck.com\", role = c(\"aut\")),\nperson(\"Jianxiao\", \"Yang\", email = \"yangjx@ucla.edu\", role = c(\"aut\")),\nperson(\"Amin\", \"Shirazi\", email = \"ashirazist@gmail.com\", role = c(\"ctb\")),\nperson(\"Ruixue\", \"Wang\", email = \"ruixue.wang@merck.com\", role = c(\"ctb\")),\nperson(\"Yi\", \"Cui\", email = \"yi.cui@merck.com\", role = c(\"ctb\")),\nperson(\"Ping\", \"Yang\", email = \"ping.yang1@merck.com\", role = c(\"ctb\")),\nperson(\"Xin Tong\", \"Li\", email = \"xin.tong.li@merck.com\", role = c(\"ctb\")),\nperson(\"Chenxiang\", \"Li\", email = \"chenxiang.li@merck.com\", role = c(\"ctb\")),\nperson(\"Hiroaki\", \"Fukuda\", email = \"hiroaki.fukuda@merck.com\", role = c(\"ctb\")),\nperson(\"Hongtao\", \"Zhang\", email = \"hongtao.zhang1@merck.com\", role = c(\"ctb\")),\nperson(\"Yalin\", \"Zhu\", email = \"yalin.zhu@outlook.com\", role = c(\"ctb\")),\nperson(\"Shiyu\", \"Zhang\", email = \"shiyu.zhang@merck.com\", role = c(\"ctb\")),\nperson(\"Dickson\", \"Wanjau\", email = \"dickson.wanjau@merck.com\", role = c(\"ctb\")),\nperson(\"Merck & Co., Inc., Rahway, NJ, USA and its affiliates\", role = \"cph\",\ncomment = c(ROR = \"02891sr49\"))\n)", "Description": "The goal of 'gsDesign2' is to enable fixed or group\nsequential design under non-proportional hazards. To enable\nhighly flexible enrollment, time-to-event and time-to-dropout\nassumptions, 'gsDesign2' offers piecewise constant enrollment,\nfailure rates, and dropout rates for a stratified population.\nThis package includes three methods for designs: average hazard\nratio, weighted logrank tests in Yung and Liu (2019)\n, and MaxCombo tests. Substantial\nflexibility on top of what is in the 'gsDesign' package is\nintended for selecting boundaries.", "License": "GPL-3", "URL": "https://merck.github.io/gsDesign2/,\nhttps://github.com/Merck/gsDesign2", "BugReports": "https://github.com/Merck/gsDesign2/issues", "Encoding": "UTF-8", "VignetteBuilder": "knitr", "RoxygenNote": "7.3.3", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-07-01 07:32:51 UTC", "User": "root" }, "Author": "Keaven Anderson [aut], Yujie Zhao [aut, cre], Yilong Zhang\n[aut], John Blischak [aut], Yihui Xie [aut], Nan Xiao [aut],\nJianxiao Yang [aut], Amin Shirazi [ctb], Ruixue Wang [ctb], Yi\nCui [ctb], Ping Yang [ctb], Xin Tong Li [ctb], Chenxiang Li\n[ctb], Hiroaki Fukuda [ctb], Hongtao Zhang [ctb], Yalin Zhu\n[ctb], Shiyu Zhang [ctb], Dickson Wanjau [ctb], Merck & Co.,\nInc., Rahway, NJ, USA and its affiliates [cph] (ROR:\n)", "Maintainer": "Yujie Zhao ", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2026-06-30 22:40:02 UTC", "RemoteUrl": "https://github.com/cran/gsDesign2", "RemoteRef": "HEAD", "RemoteSha": "183cd3792f8b424d790552d7dea2b8d405c850d6", "_user": "cran", "_type": "src", "_file": "gsDesign2_1.1.9.tar.gz", "_fileid": "https://r2.ropensci.org/ecf4befd1fb0515b73e9e392160413b898f6fc8f141666a804e958c4521c409c", "_filesize": 859498, "_sha256": "ecf4befd1fb0515b73e9e392160413b898f6fc8f141666a804e958c4521c409c", "_expires": "2026-10-10T20:12:45.000Z", "_created": "2026-07-01T07:32:51.000Z", "_published": "2026-07-02T20:12:46.565Z", "_jobs": [ { "job": 84868526984, "time": 301, "config": "linux-devel-arm64", "r": "4.7.0", "check": "ERROR", "artifact": "8003214666" }, { "job": 84868526782, "time": 271, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "8003201586" }, { "job": 84868526848, "time": 304, "config": "linux-release-arm64", "r": "4.6.1", "check": "ERROR", "artifact": "8003215180" }, { "job": 84868527122, "time": 286, "config": "linux-release-x86_64", "r": "4.6.1", "check": "OK", "artifact": "8003207005" }, { "job": 84868525855, "time": 230, "config": "source", "r": "4.6.1", "check": "OK", "artifact": "8003102936" }, { "job": 84868526721, "time": 172, "config": "wasm-release", "r": "4.6.0", "check": "OK", "artifact": "8003165003" } ], "_host": "GitHub-Actions", "_buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317", "_status": "success", "_upstream": "https://github.com/cran/gsDesign2", "_commit": { "id": "183cd3792f8b424d790552d7dea2b8d405c850d6", "author": "Yujie Zhao ", "committer": "cran-robot ", "message": "version 1.1.9\n", "time": 1782859202 }, "_maintainer": { "name": "Yujie Zhao", "email": "yujie.zhao@merck.com", "login": "littlebeannie", "description": "Statistician", "uuid": 43153957 }, "_distro": "resolute", "_registered": true, "_dependencies": [ { "package": "R", "version": ">= 4.1.0", "role": "Depends" }, { "package": "Rcpp", "role": "LinkingTo" }, { "package": "corpcor", "role": "Imports" }, { "package": "data.table", "role": "Imports" }, { "package": "dplyr", "role": "Imports" }, { "package": "gsDesign", "role": "Imports" }, { "package": "gt", "role": "Imports" }, { "package": "methods", "role": "Imports" }, { "package": "mvtnorm", "role": "Imports" }, { "package": "npsurvSS", "version": ">= 1.1.0", "role": "Imports" }, { "package": "r2rtf", "role": "Imports" }, { "package": "stats", "role": "Imports" }, { "package": "survival", "role": "Imports" }, { "package": "tibble", "role": "Imports" }, { "package": "tidyr", "role": "Imports" }, { "package": "utils", "role": "Imports" }, { "package": "Rcpp", "role": "Imports" }, { "package": "covr", "role": "Suggests" }, { "package": "ggplot2", "role": "Suggests" }, { "package": "cowplot", "role": "Suggests" }, { "package": "kableExtra", "role": "Suggests" }, { "package": "knitr", "role": "Suggests" }, { "package": "rmarkdown", "role": "Suggests" }, { "package": "simtrial", "role": "Suggests" }, { "package": "testit", "version": ">= 1.0", "role": "Suggests" } ], "_owner": "cran", "_selfowned": false, "_usedby": 0, "_updates": [ { "week": "2025-37", "n": 1 }, { "week": "2025-47", "n": 1 }, { "week": "2026-07", "n": 1 }, { "week": "2026-27", "n": 1 } ], "_tags": [ { "name": "1.1.6", "date": "2025-09-11" }, { "name": "1.1.7", "date": "2025-11-19" }, { "name": "1.1.8", "date": "2026-02-12" }, { "name": "1.1.9", "date": "2026-06-30" } ], "_stars": 0, "_contributors": [ { "user": "littlebeannie", "count": 13, "uuid": 43153957 } ], "_userbio": { "uuid": 6899542, "type": "organization", "name": "cran", "followers": 615, "description": "Unofficial read-only mirror of all CRAN R packages" }, "_downloads": { "count": 491, "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/gsDesign2" }, "_devurl": "https://github.com/merck/gsdesign2", "_pkgdown": "https://merck.github.io/gsDesign2/", "_searchresults": 265, "_topics": [ "cpp" ], "_rbuild": "4.6.1", "_assets": [ "extra/citation.cff", "extra/citation.html", "extra/citation.json", "extra/citation.txt", "extra/contents.json", "extra/gsDesign2.html", "extra/NEWS.html", "extra/NEWS.txt", "extra/readme.html", "extra/readme.md", "manual.pdf" ], "_homeurl": "https://github.com/merck/gsdesign2", "_realowner": "merck", "_cranurl": false, "_releases": [ { "version": "1.0.7", "date": "2023-03-20" }, { "version": "1.0.8", "date": "2023-05-01" }, { "version": "1.0.9", "date": "2023-06-20" }, { "version": "1.1.0", "date": "2023-08-24" }, { "version": "1.1.1", "date": "2024-02-09" }, { "version": "1.1.2", "date": "2024-04-09" }, { "version": "1.1.3", "date": "2024-11-15" }, { "version": "1.1.4", "date": "2025-06-06" }, { "version": "1.1.5", "date": "2025-06-27" }, { "version": "1.1.6", "date": "2025-09-11" }, { "version": "1.1.7", "date": "2025-11-19" }, { "version": "1.1.8", "date": "2026-02-16" }, { "version": "1.1.9", "date": "2026-06-30" } ], "_exports": [ "ahr", "ahr_blinded", "as_gt", "as_rtf", "define_enroll_rate", "define_fail_rate", "expected_accrual", "expected_event", "expected_time", "fixed_design_ahr", "fixed_design_fh", "fixed_design_lf", "fixed_design_maxcombo", "fixed_design_mb", "fixed_design_milestone", "fixed_design_rd", "fixed_design_rmst", "gs_b", "gs_bound_summary", "gs_cp", "gs_cp_simple", "gs_create_arm", "gs_design_ahr", "gs_design_combo", "gs_design_npe", "gs_design_rd", "gs_design_wlr", "gs_info_ahr", "gs_info_combo", "gs_info_rd", "gs_info_wlr", "gs_power_ahr", "gs_power_combo", "gs_power_npe", "gs_power_rd", "gs_power_wlr", "gs_spending_bound", "gs_spending_combo", "gs_update_ahr", "ppwe", "pw_info", "s2pwe", "sequential_pval", "text_summary", "to_integer", "wlr_weight_1", "wlr_weight_fh", "wlr_weight_mb", "wlr_weight_n" ], "_help": [ { "page": "ahr", "title": "Average hazard ratio under non-proportional hazards", "topics": [ "ahr" ] }, { "page": "ahr_blinded", "title": "Blinded estimation of average hazard ratio", "topics": [ "ahr_blinded" ] }, { "page": "as_gt", "title": "Convert summary table of a fixed or group sequential design object to a gt object", "topics": [ "as_gt", "as_gt.fixed_design_summary", "as_gt.gs_design_summary" ] }, { "page": "as_rtf", "title": "Write summary table of a fixed or group sequential design object to an RTF file", "topics": [ "as_rtf", "as_rtf.fixed_design_summary", "as_rtf.gs_design_summary" ] }, { "page": "define_enroll_rate", "title": "Define enrollment rate", "topics": [ "define_enroll_rate" ] }, { "page": "define_fail_rate", "title": "Define failure rate", "topics": [ "define_fail_rate" ] }, { "page": "expected_accrual", "title": "Piecewise constant expected accrual", "topics": [ "expected_accrual" ] }, { "page": "expected_event", "title": "Expected events observed under piecewise exponential model", "topics": [ "expected_event" ] }, { "page": "expected_time", "title": "Predict time at which a targeted event count is achieved", "topics": [ "expected_time" ] }, { "page": "fixed_design", "title": "Fixed design under non-proportional hazards", "topics": [ "fixed_design_ahr", "fixed_design_fh", "fixed_design_lf", "fixed_design_maxcombo", "fixed_design_mb", "fixed_design_milestone", "fixed_design_rd", "fixed_design_rmst" ] }, { "page": "gs_b", "title": "Default boundary generation", "topics": [ "gs_b" ] }, { "page": "gs_bound_summary", "title": "Bound summary table", "topics": [ "gs_bound_summary" ] }, { "page": "gs_cp", "title": "Conditional power computation with non-constant effect size for non-/crossing an upper boundary at analysis j given observed Z value at analysis i", "topics": [ "gs_cp" ] }, { "page": "gs_cp_simple", "title": "Simple conditional power computation with non-constant effect size", "topics": [ "gs_cp_simple" ] }, { "page": "gs_create_arm", "title": "Create npsurvSS arm object", "topics": [ "gs_create_arm" ] }, { "page": "gs_design_ahr", "title": "Calculate sample size and bounds given targeted power and Type I error in group sequential design using average hazard ratio under non-proportional hazards", "topics": [ "gs_design_ahr" ] }, { "page": "gs_design_combo", "title": "Group sequential design using MaxCombo test under non-proportional hazards", "topics": [ "gs_design_combo" ] }, { "page": "gs_power_design_npe", "title": "Group sequential design computation with non-constant effect and information.", "topics": [ "gs_design_npe", "gs_power_design_npe", "gs_power_npe" ] }, { "page": "gs_design_rd", "title": "Group sequential design of binary outcome measuring in risk difference", "topics": [ "gs_design_rd" ] }, { "page": "gs_design_wlr", "title": "Group sequential design using weighted log-rank test under non-proportional hazards", "topics": [ "gs_design_wlr" ] }, { "page": "gs_info_ahr", "title": "Information and effect size based on AHR approximation", "topics": [ "gs_info_ahr" ] }, { "page": "gs_info_combo", "title": "Information and effect size for MaxCombo test", "topics": [ "gs_info_combo" ] }, { "page": "gs_info_rd", "title": "Information and effect size under risk difference", "topics": [ "gs_info_rd" ] }, { "page": "gs_info_wlr", "title": "Information and effect size for weighted log-rank test", "topics": [ "gs_info_wlr" ] }, { "page": "gs_power_ahr", "title": "Group sequential design power using average hazard ratio under non-proportional hazards", "topics": [ "gs_power_ahr" ] }, { "page": "gs_power_combo", "title": "Group sequential design power using MaxCombo test under non-proportional hazards", "topics": [ "gs_power_combo" ] }, { "page": "gs_power_rd", "title": "Group sequential design power of binary outcome measuring in risk difference", "topics": [ "gs_power_rd" ] }, { "page": "gs_power_wlr", "title": "Group sequential design power using weighted log rank test under non-proportional hazards", "topics": [ "gs_power_wlr" ] }, { "page": "gs_spending_bound", "title": "Derive spending bound for group sequential boundary", "topics": [ "gs_spending_bound" ] }, { "page": "gs_spending_combo", "title": "Derive spending bound for MaxCombo group sequential boundary", "topics": [ "gs_spending_combo" ] }, { "page": "gs_update_ahr", "title": "Group sequential design using average hazard ratio under non-proportional hazards", "topics": [ "gs_update_ahr" ] }, { "page": "ppwe", "title": "Piecewise exponential cumulative distribution function", "topics": [ "ppwe" ] }, { "page": "pw_info", "title": "Average hazard ratio under non-proportional hazards", "topics": [ "pw_info" ] }, { "page": "s2pwe", "title": "Approximate survival distribution with piecewise exponential distribution", "topics": [ "s2pwe" ] }, { "page": "sequential_pval", "title": "Sequential p-value computation for gsDesign2", "topics": [ "sequential_pval" ] }, { "page": "summary", "title": "Summary for fixed design or group sequential design objects", "topics": [ "summary.fixed_design", "summary.gs_design" ] }, { "page": "text_summary", "title": "Generates a textual summary of a group sequential design using the AHR method.", "topics": [ "text_summary" ] }, { "page": "to_integer", "title": "Round sample size and events", "topics": [ "to_integer", "to_integer.fixed_design", "to_integer.gs_design" ] }, { "page": "wlr_weight", "title": "Weight functions for weighted log-rank test", "topics": [ "wlr_weight", "wlr_weight_1", "wlr_weight_fh", "wlr_weight_mb", "wlr_weight_n" ] } ], "_pkglogo": "https://github.com/cran/gsDesign2/raw/HEAD/man/figures/logo.png", "_readme": "https://github.com/cran/gsDesign2/raw/HEAD/README.md", "_rundeps": [ "base64enc", "bigD", "bitops", "bslib", "cachem", "cli", "commonmark", "corpcor", "cpp11", "curl", "data.table", "digest", "dplyr", "evaluate", "farver", "fastmap", "fontawesome", "fs", "generics", "ggplot2", "glue", "gsDesign", "gt", "gtable", "highr", "htmltools", "htmlwidgets", "isoband", "jquerylib", "jsonlite", "juicyjuice", "knitr", "labeling", "lattice", "lifecycle", "litedown", "magrittr", "markdown", "Matrix", "memoise", "mime", "mvtnorm", "npsurvSS", "pillar", "pkgconfig", "purrr", "r2rtf", "R6", "rappdirs", "RColorBrewer", "Rcpp", "reactable", "reactR", "rlang", "rmarkdown", "S7", "sass", "scales", "stringi", "stringr", "survival", "tibble", "tidyr", "tidyselect", "tinytex", "utf8", "V8", "vctrs", "viridisLite", "withr", "xfun", "xml2", "xtable", "yaml" ], "_sysdeps": [ { "shlib": "libstdc++", "package": "libstdc++6", "source": "gcc", "version": "16-20260322-1ubuntu1", "name": "c++", "homepage": "http://gcc.gnu.org/", "description": "GNU Standard C++ Library v3" } ], "_vignettes": [ { "source": "gsDesign2.Rmd", "filename": "gsDesign2.html", "title": "Quick start for NPH sample size and power", "author": "Keaven M. Anderson", "engine": "knitr::rmarkdown", "headings": [ "Overview", "Packages used", "Enrollment rates", "Failure and dropout rates", "Fixed design", "Group sequential design", "Simple efficacy bound definition", "Two-sided testing", "Symmetric 2-sided bounds", "Asymmetric 2-sided bounds", "References" ], "created": "2023-03-20 09:50:06", "modified": "2025-09-11 16:38:15", "commits": 6 } ], "_score": 4.724275869600789, "_indexed": false, "_nocasepkg": "gsdesign2", "_universes": [ "cran" ], "_indexurl": "https://merck.r-universe.dev/gsDesign2", "_binaries": [ { "r": "4.7.0", "os": "linux", "version": "1.1.9", "date": "2026-07-01T07:36:19.000Z", "distro": "resolute", "arch": "aarch64", "commit": "183cd3792f8b424d790552d7dea2b8d405c850d6", "fileid": "https://r2.ropensci.org/f147ca7c56761dcae9b98f7ed6c95279f3d8e02a1b3d23594ce7d5c46b3445d7", "status": "failure", "check": "ERROR", "buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317" }, { "r": "4.7.0", "os": "linux", "version": "1.1.9", "date": "2026-07-01T07:35:44.000Z", "distro": "resolute", "arch": "x86_64", "commit": "183cd3792f8b424d790552d7dea2b8d405c850d6", "fileid": "https://r2.ropensci.org/ab9236f3427df4d6e001af76783ade1c900af07a3a76b1c4cc35d44e4ccf4622", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317" }, { "r": "4.6.1", "os": "linux", "version": "1.1.9", "date": "2026-07-01T07:36:19.000Z", "distro": "resolute", "arch": "aarch64", "commit": "183cd3792f8b424d790552d7dea2b8d405c850d6", "fileid": "https://r2.ropensci.org/9a344b6e9e3f4f0f360669dd4eb08b63bcb748bf91ecb6ab168bd7d0c9287d3a", "status": "failure", "check": "ERROR", "buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317" }, { "r": "4.6.1", "os": "linux", "version": "1.1.9", "date": "2026-07-01T07:35:29.000Z", "distro": "resolute", "arch": "x86_64", "commit": "183cd3792f8b424d790552d7dea2b8d405c850d6", "fileid": "https://r2.ropensci.org/10656c928e8e73ecea0bb05d35fe6d89599a7333596968b7749b141836085c27", "status": "success", "check": "OK", "buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317" }, { "r": "4.6.0", "os": "wasm", "version": "1.1.9", "date": "2026-07-01T07:36:05.000Z", "arch": "emscripten", "commit": "183cd3792f8b424d790552d7dea2b8d405c850d6", "fileid": "https://r2.ropensci.org/5af9f9c61020976697ddd7b6e1947fad6d169bb7142ca0799a4f9643c69f6a8f", "status": "success", "buildurl": "https://github.com/r-universe/cran/actions/runs/28501087317" } ] }