{
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  "Package": "ewoc",
  "Type": "Package",
  "Title": "Escalation with Overdose Control",
  "Version": "0.3.0",
  "Author": "Marcio A. Diniz <marcio.diniz@cshs.org>",
  "Maintainer": "Marcio A. Diniz <marcio.diniz@cshs.org>",
  "Description": "An implementation of a variety of escalation with overdose\ncontrol designs introduced by Babb, Rogatko and Zacks (1998)\n<doi:10.1002/(SICI)1097-0258(19980530)17:10%3C1103::AID-SIM793%3E3.0.CO;2-9>.\nIt calculates the next dose as a clinical trial proceeds and\nperforms simulations to obtain operating characteristics.",
  "License": "GPL (>= 2)",
  "URL": "https://github.com/dnzmarcio/ewoc/",
  "BugReports": "https://github.com/dnzmarcio/ewoc/issues",
  "RoxygenNote": "7.1.0",
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    "User": "root"
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  "Date/Publication": "2020-06-07 06:20:02 UTC",
  "RemoteUrl": "https://github.com/cran/ewoc",
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    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
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    "extra/NEWS.html",
    "extra/NEWS.txt",
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    "extra/readme.md",
    "manual.pdf"
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    "dlt_curve_d1extended",
    "dlt_curve_d1ph",
    "dlt_rate",
    "ewoc_d1classical",
    "ewoc_d1extended",
    "ewoc_d1ph",
    "ewoc_simulation",
    "inv_standard_dose",
    "logit",
    "mtd_bias",
    "mtd_mse",
    "mtd_rho_d1extended",
    "opc",
    "optimal_mtd",
    "optimal_toxicity",
    "pdlt_d1classical",
    "pdlt_d1extended",
    "pdlt_d1ph",
    "response_d1classical",
    "response_d1extended",
    "response_d1ph",
    "standard_dose",
    "stop_rule",
    "stop_rule_d1classical",
    "stop_rule_d1extended",
    "stop_rule_d1ph"
  ],
  "_help": [
    {
      "page": "accuracy_index",
      "title": "Accuracy Index",
      "topics": [
        "accuracy_index"
      ]
    },
    {
      "page": "average_toxicity",
      "title": "Average Toxicity Number",
      "topics": [
        "average_toxicity"
      ]
    },
    {
      "page": "dlt_curve_d1classical",
      "title": "Plot the DLT curve based on the EWOC classical model",
      "topics": [
        "dlt_curve_d1classical"
      ]
    },
    {
      "page": "dlt_curve_d1extended",
      "title": "Plot the DLT curve based on the EWOC extended model",
      "topics": [
        "dlt_curve_d1extended"
      ]
    },
    {
      "page": "dlt_curve_d1ph",
      "title": "Plot the DLT curve based on the EWOC proportional hazards model",
      "topics": [
        "dlt_curve_d1ph"
      ]
    },
    {
      "page": "dlt_rate",
      "title": "Evaluation of the DLT rate",
      "topics": [
        "dlt_rate"
      ]
    },
    {
      "page": "ewoc_d1classical",
      "title": "Escalation With Overdose Control",
      "topics": [
        "ewoc_d1classical"
      ]
    },
    {
      "page": "ewoc_d1extended",
      "title": "Escalation With Overdose Control",
      "topics": [
        "ewoc_d1extended"
      ]
    },
    {
      "page": "ewoc_d1ph",
      "title": "Escalation With Overdose Control",
      "topics": [
        "ewoc_d1ph"
      ]
    },
    {
      "page": "ewoc_simulation",
      "title": "EWOC simulation",
      "topics": [
        "ewoc_simulation"
      ]
    },
    {
      "page": "inv_standard_dose",
      "title": "Inverse standardization of the dose",
      "topics": [
        "inv_standard_dose"
      ]
    },
    {
      "page": "logit",
      "title": "Logit",
      "topics": [
        "logit"
      ]
    },
    {
      "page": "mtd_bias",
      "title": "Bias of the MTD estimates",
      "topics": [
        "mtd_bias"
      ]
    },
    {
      "page": "mtd_mse",
      "title": "Mean Square Error of the MTD estimates",
      "topics": [
        "mtd_mse"
      ]
    },
    {
      "page": "mtd_rho_d1extended",
      "title": "Convert mtd to rho_1 and vice-versa",
      "topics": [
        "mtd_rho_d1extended"
      ]
    },
    {
      "page": "opc",
      "title": "Operating characteristics for EWOC simulations",
      "topics": [
        "opc"
      ]
    },
    {
      "page": "optimal_mtd",
      "title": "Percent of doses in relation the optimal MTD interval",
      "topics": [
        "optimal_mtd"
      ]
    },
    {
      "page": "optimal_toxicity",
      "title": "Percent of doses in relation the optimal toxicity interval",
      "topics": [
        "optimal_toxicity"
      ]
    },
    {
      "page": "pdlt_d1classical",
      "title": "Generating a probability of DLT function based on the EWOC classical model",
      "topics": [
        "pdlt_d1classical"
      ]
    },
    {
      "page": "pdlt_d1extended",
      "title": "Generating a probability of DLT function based on the EWOC extended model",
      "topics": [
        "pdlt_d1extended"
      ]
    },
    {
      "page": "pdlt_d1ph",
      "title": "Generating a probability of DLT function based on the EWOC Proportional Hazards model",
      "topics": [
        "pdlt_d1ph"
      ]
    },
    {
      "page": "response_d1classical",
      "title": "Generating a binary response function based on the EWOC classical model",
      "topics": [
        "response_d1classical"
      ]
    },
    {
      "page": "response_d1extended",
      "title": "Generating a binary response function based on the EWOC extended model",
      "topics": [
        "response_d1extended"
      ]
    },
    {
      "page": "response_d1ph",
      "title": "Generating a response function based on the EWOC Proportional Hazards model",
      "topics": [
        "response_d1ph"
      ]
    },
    {
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      "title": "Standardization of the dose",
      "topics": [
        "standard_dose"
      ]
    },
    {
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      "title": "Evaluation of the stopping rule",
      "topics": [
        "stop_rule"
      ]
    },
    {
      "page": "stop_rule_d1classical",
      "title": "Generating a stop rule function for EWOC classical model",
      "topics": [
        "stop_rule_d1classical"
      ]
    },
    {
      "page": "stop_rule_d1extended",
      "title": "Generating a stop rule function for EWOC extended model",
      "topics": [
        "stop_rule_d1extended"
      ]
    },
    {
      "page": "stop_rule_d1ph",
      "title": "Generating a stop rule function for EWOC proportional hazards model",
      "topics": [
        "stop_rule_d1ph"
      ]
    }
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