{ "_id": "6a1d6ff11d7bb097a0a501af", "Type": "Package", "Package": "bonsaiforest", "Title": "Shrinkage Based Forest Plots", "Version": "0.1.1", "Date": "2024-09-25", "Authors@R": "c(\nperson(\"Mar\", \"Vazquez Rabunal\", , \"mar.vazquez_rabunal@roche.com\", role = \"aut\"),\nperson(\"Daniel\", \"Sabanés Bové\", , \"daniel.sabanes_bove@roche.com\", role = \"aut\"),\nperson(\"Marcel\", \"Wolbers\", , \"marcel.wolbers@roche.com\", role = \"aut\"),\nperson(\"Isaac\", \"Gravestock\", , \"isaac.gravestock@roche.com\", role = \"cre\"),\nperson(\"F. Hoffmann-La Roche AG\", role = c(\"cph\", \"fnd\"))\n)", "Description": "Subgroup analyses are routinely performed in clinical\ntrial analyses. From a methodological perspective, two key\nissues of subgroup analyses are multiplicity (even if only\npredefined subgroups are investigated) and the low sample sizes\nof subgroups which lead to highly variable estimates, see e.g.\nYusuf et al (1991) . 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