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calibration: overview", "Manual evaluation of a two-stage design", "Optimal frequentist design", "Interpreting the frequentist design", "Practical recommendations for frequentist calibration", "References" ], "created": "2026-06-01 19:40:02", "modified": "2026-06-23 16:10:02", "commits": 2 }, { "source": "bfbin2arm-singlearm_twostage_full.Rmd", "filename": "bfbin2arm-singlearm_twostage_full.html", "title": "Optimal full calibration for single-arm two-stage Bayes factor designs with binary endpoints", "author": "Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany", "engine": "knitr::rmarkdown", "headings": [ "Introduction: Hybrid and full calibration", "Bayesian calibration", "Hybrid Bayes-frequentist calibration", "Current implementation", "Full Bayesian and frequentist calibration", "Overview of the different calibration modes", "Full calibration example", "Why the design is selected", "Comparison of calibration modes", "Practical recommendations for full calibration", "References" ], "created": "2026-06-01 19:40:02", "modified": "2026-06-23 16:10:02", "commits": 2 }, { "source": "bfbin2arm-singlearm_twostage_hybrid.Rmd", "filename": "bfbin2arm-singlearm_twostage_hybrid.html", "title": "Optimal hybrid calibration for single-arm two-stage Bayes factor designs with binary endpoints", "author": "Riko Kelter Institute of Medical Statistics and Computational Biology Faculty of Medicine, University of Cologne Cologne, Germany", "engine": "knitr::rmarkdown", "headings": [ "Hybrid calibration: Overview", "Basics of hybrid calibration", "Finding an optimal hybrid design", "Interpretation of hybrid calibration", "Bayesian and frequentist expected sample sizes", "Frequentist expected sample size", "Bayesian expected sample size", "Sensitivity to the $H_1$ design prior", "Adding a compelling-evidence constraint under $H_0$", "Power cushions in hybrid calibration", "Interpretation of the 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