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}, { "page": "ATSS_Design_Stage1", "title": "Adaptive Threshold and Sample Size Simon Design Interim Analysis", "topics": [ "ATSS_Design_Stage1" ] }, { "page": "ATSS_Design_Stage2", "title": "Adaptive Threshold and Sample Size Simon Design Two Stages", "topics": [ "ATSS_Design_Stage2" ] }, { "page": "SimonAnalysis", "title": "Post-Trial Inference for ATS and ATSS Simon Designs", "topics": [ "SimonAnalysis" ] } ], "_rundeps": [], "_vignettes": [ { "source": "UnplanSimon.Rmd", "filename": "UnplanSimon.html", "title": "UnplanSimon", "author": "Yunhe Liu, Haitao Pan", "engine": "knitr::rmarkdown", "headings": [ "Introduction", "Overview of Simon's Two-Stage Design", "Design Parameters and Constraints", "Example 1 (Designing a Study Using Simon's Two-Stage Design)", "Adaptive Threshold Simon Design (ATS Simon)", "Example 2 (ATS Simon design for Addressing Under-or Over-Enrollment in Simon's Two-Stage Design based on Alpha Spending Function)", "Example 2.1 (Under-enrollment in $1^{st}$ stage)", "Example 2.2 (Under-enrollment in both $1^{st}$ and $2^{nd}$ stages)", "Example 2.3 (Under-enrollment in $1^{st}$ and Over-enrollment in $2^{nd}$ stage)", "Adaptive\tThreshold\tand\tSample Size Simon Design (ATSS Simon)", "Example 3 (Adaptive Threshold and Sample Size Simon Design (ATSS Simon) for Under- and/or Over-enrollment)", "Example 3.1 (Under-enrollment at $1^{st}$ stage)", "Example 3.2 (Under-enrollment at\t$1^{st}$ and $2^{nd}$ stages)", "Example 3.3 (Under-enrollment at\t$1^{st}$ and Over-enrollment at $2^{nd}$ stage)", "Summary", "Post-Trial Inference for ATS and ATSS Simon Designs with Under- and Over-Enrollment", "Point Estimate", "Confidence intervals:", "$p$-Value:", "Example 4 (Post-Trial Inference usage for ATS and ATSS Simon Designs)", "Example 4.1 (Post-Trial Inference for ATS Simon Design with Under-Enrollment)", "Example 4.2 (Post-Trial Inference for ATSS Simon Design with Under-Enrollment)", "References" ], "created": "2024-10-25 09:10:06", "modified": 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