{
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  "Package": "SSHAARP",
  "Version": "2.0.8",
  "Date": "2025-06-17",
  "Title": "Searching Shared HLA Amino Acid Residue Prevalence",
  "Authors@R": "c(person(\"Livia\", \"Tran\",\nrole = c(\"aut\", \"cre\"),\nemail = \"livia.tran@ucsf.edu\"),\nperson(\"Steven\", \"Mack\",\nrole= \"aut\",\nemail = \"steven.mack@ucsf.edu\"),\nperson(\"Josh\", \"Bredeweg\", role= \"ctb\"),\nperson(\"Dale\", \"Steinhardt\", role= \"ctb\"))",
  "Maintainer": "Livia Tran <livia.tran@ucsf.edu>",
  "Description": "Processes amino acid alignments produced by the\n'IPD-IMGT/HLA (Immuno Polymorphism-ImMunoGeneTics/Human\nLeukocyte Antigen) Database' to identify user-defined amino\nacid residue motifs shared across HLA alleles, HLA alleles, or\nHLA haplotypes, and calculates frequencies based on HLA allele\nfrequency data. 'SSHAARP' (Searching Shared HLA Amino Acid\nResidue Prevalence) uses 'Generic Mapping Tools (GMT)' software\nand the 'GMT' R package to generate global frequency heat maps\nthat illustrate the distribution of each user-defined map\naround the globe. 'SSHAARP' analyzes the allele frequency data\ndescribed by Solberg et al. (2008)\n<doi:10.1016/j.humimm.2008.05.001>, a global set of 497\npopulation samples from 185 published datasets, representing\n66,800 individuals total. Users may also specify their own\ndatasets, but file conventions must follow the prebundled\nSolberg dataset, or the mock haplotype dataset.",
  "License": "GPL (>= 3)",
  "Encoding": "UTF-8",
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  "NeedsCompilation": "no",
  "Packaged": {
    "Date": "2026-05-22 10:09:40 UTC",
    "User": "root"
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  "Author": "Livia Tran [aut, cre], Steven Mack [aut], Josh Bredeweg [ctb],\nDale Steinhardt [ctb]",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2025-06-18 02:21:45 UTC",
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    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 2.0.8\n",
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    "name": "Livia Tran",
    "email": "livia.tran@ucsf.edu"
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      "date": "2024-12-11"
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  "_exports": [
    "checkAlleleSyntax",
    "checkHaplotypeSyntax",
    "checkLocusDataset",
    "checkMotifSyntax",
    "checkPosition",
    "dataSubset",
    "dataSubsetHaplo",
    "findMotif",
    "getVariantInfo",
    "isNamePresent",
    "PALM",
    "readFilename",
    "validateVariantType",
    "verifyAlleleANHIG",
    "verifyAlleleANHIGHaplo",
    "verifyAlleleDataset"
  ],
  "_datasets": [
    {
      "name": "mock_haplotype_dataset",
      "title": "Mock Haplotype Dataset",
      "object": "mock_haplotype_dataset",
      "class": [
        "data.frame"
      ],
      "fields": [
        "pop_id",
        "poly_region",
        "haplotype",
        "sample_size",
        "frequency",
        "Lat",
        "Long"
      ],
      "rows": 24989,
      "table": true,
      "tojson": true
    },
    {
      "name": "solberg_dataset",
      "title": "Solberg Dataset",
      "object": "solberg_dataset",
      "class": [
        "data.frame"
      ],
      "fields": [
        "dataset",
        "popname",
        "contin",
        "complex",
        "latit",
        "longit",
        "coord",
        "locus",
        "allele_v2",
        "allele_v3",
        "allele.freq",
        "allele.count",
        "gametes"
      ],
      "rows": 20163,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "checkAlleleSyntax",
      "title": "Check allele syntax",
      "topics": [
        "checkAlleleSyntax"
      ]
    },
    {
      "page": "checkHaplotypeSyntax",
      "title": "Check haplotype syntax",
      "topics": [
        "checkHaplotypeSyntax"
      ]
    },
    {
      "page": "checkLocusDataset",
      "title": "Check locus validity and if the locus is present in the user specified dataset",
      "topics": [
        "checkLocusDataset"
      ]
    },
    {
      "page": "checkMotifSyntax",
      "title": "Check motif syntax",
      "topics": [
        "checkMotifSyntax"
      ]
    },
    {
      "page": "checkPosition",
      "title": "Checks if amino acid positions in motif exist",
      "topics": [
        "checkPosition"
      ]
    },
    {
      "page": "dataSubset",
      "title": "Dataset manipulation for motifs and alleles",
      "topics": [
        "dataSubset"
      ]
    },
    {
      "page": "dataSubsetHaplo",
      "title": "Dataset manipulation for haplotypes",
      "topics": [
        "dataSubsetHaplo"
      ]
    },
    {
      "page": "findMotif",
      "title": "Returns an alignment data frame of alleles that share a specific amino acid motif",
      "topics": [
        "findMotif"
      ]
    },
    {
      "page": "getVariantInfo",
      "title": "Locus and allele or motif extraction for motifs, allele, or haplotype mapping",
      "topics": [
        "getVariantInfo"
      ]
    },
    {
      "page": "isNamePresent",
      "title": "Checks if name portion of entered variant is present",
      "topics": [
        "isNamePresent"
      ]
    },
    {
      "page": "mock_haplotype_dataset",
      "title": "Mock Haplotype Dataset",
      "topics": [
        "mock_haplotype_dataset"
      ]
    },
    {
      "page": "PALM",
      "title": "Population Allele Locating Mapmaker",
      "topics": [
        "PALM"
      ]
    },
    {
      "page": "readFilename",
      "title": "Designates dataset by either reading in file the user has provided, or using the Solberg dataset or mock haplotype dataset",
      "topics": [
        "readFilename"
      ]
    },
    {
      "page": "solberg_dataset",
      "title": "Solberg Dataset",
      "topics": [
        "solberg_dataset"
      ]
    },
    {
      "page": "validateVariantType",
      "title": "validateVariantType",
      "topics": [
        "validateVariantType"
      ]
    },
    {
      "page": "verifyAlleleANHIG",
      "title": "Verifies the allele entered is present in the IMGT protein alignments",
      "topics": [
        "verifyAlleleANHIG"
      ]
    },
    {
      "page": "verifyAlleleANHIGHaplo",
      "title": "Verifies the alleles in entered haplotype are present in IMGTprotalignments",
      "topics": [
        "verifyAlleleANHIGHaplo"
      ]
    },
    {
      "page": "verifyAlleleDataset",
      "title": "Verifies the allele entered is present in specified dataset",
      "topics": [
        "verifyAlleleDataset"
      ]
    }
  ],
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      "source": "vignette.Rmd",
      "filename": "vignette.html",
      "title": "SSHAARP: Searching Shared HLA Amino Acid Residue Prevalence",
      "author": "Livia Tran - livia.tran@uscf.edu",
      "engine": "knitr::rmarkdown",
      "headings": [
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        "Functions",
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      "created": "2020-04-27 16:10:02",
      "modified": "2025-06-18 02:21:45",
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