{ "_id": "6a16ca54acfb0bcc41d89749", "Package": "Rcurvep", "Type": "Package", "Title": "Concentration-Response Data Analysis using Curvep", "Version": "1.3.2", "Authors@R": "c(\nperson(\"Jui-Hua\", \"Hsieh\", email = \"juihua.hsieh@gmail.com\", role = c(\"aut\", \"cre\"), comment = c(ORCID = \"0000-0003-1620-1571\")),\nperson(\"Alexander\", \"Sedykh\", role = c(\"aut\")),\nperson(\"Fred\", \"Parham\", role = c(\"ctb\")),\nperson(\"Yuhong\", \"Wang\", role = c(\"ctb\")),\nperson(\"Tongan\", \"Zhao\", role = c(\"aut\")),\nperson(\"Ruili\", \"Huang\", role = c(\"ctb\"))\n)", "Description": "An R interface for processing concentration-response\ndatasets using Curvep, a response noise filtering algorithm.\nThe algorithm was described in the publications (Sedykh A et\nal. (2011) and Sedykh A (2016)\n). Other parametric fitting\napproaches (e.g., Hill equation) are also adopted for ease of\ncomparison. 3-parameter Hill equation from 'tcpl' package\n(Filer D et al., ) and\n4-parameter Hill equation from Curve Class2 approach (Wang Y et\nal., ) are available. Also,\nmethods for calculating the confidence interval around the\nactivity metrics are also provided. The methods are based on\nthe bootstrap approach to simulate the datasets (Hsieh J-H et\nal. ). The simulated datasets can be\nused to derive the baseline noise threshold in an assay\nendpoint. This threshold is critical in the toxicological\nstudies to derive the point-of-departure (POD).", "Language": "en-US", "BugReports": "https://github.com/moggces/Rcurvep/issues", "License": "MIT + file LICENSE", "URL": "https://github.com/moggces/Rcurvep,\nhttps://moggces.github.io/Rcurvep/", "Encoding": "UTF-8", "LazyData": "true", "RdMacros": "Rdpack", "VignetteBuilder": "knitr", "SystemRequirements": "Java", "RoxygenNote": "7.2.3", "NeedsCompilation": "no", "Packaged": { "Date": "2026-05-27 10:36:50 UTC", "User": "root" }, "Author": "Jui-Hua Hsieh [aut, cre] (ORCID:\n), Alexander Sedykh\n[aut], Fred Parham [ctb], Yuhong Wang [ctb], Tongan Zhao [aut],\nRuili Huang [ctb]", "Maintainer": "Jui-Hua Hsieh ", "Config/pak/sysreqs": "default-jdk", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2025-05-31 21:10:02 UTC", "RemoteUrl": "https://github.com/cran/Rcurvep", "RemoteRef": "HEAD", "RemoteSha": "c352e34378432c8627682107512f785892a4d471", "MD5sum": 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