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  "Package": "Phase123",
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  "Title": "Simulating and Conducting Phase 123 Trials",
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  "Date": "2019-4-25",
  "Author": "Andrew G Chapple",
  "Maintainer": "Andrew G Chapple <achapp@lsuhsc.edu>",
  "Description": "Contains three simulation functions for implementing the\nentire Phase 123 trial and the separate Eff-Tox and Phase 3\nportions of the trial, which may be beneficial for use on\nclusters. The functions AssignEffTox() and RandomizeEffTox()\nassign doses to patient cohorts during phase 12 and\nReoptimize() determines the optimal dose to continue with\nduring Phase 3. The functions ReturnMeansAgent() and\nReturnMeanControl() gives the true mean survival for the agent\ndoses and control and ReturnOCS() gives the operating\ncharacteristics of the design.",
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  "Date/Publication": "2019-04-25 16:50:04 UTC",
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    "extra/citation.json",
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    "EFFTOX",
    "PieceMCMC",
    "RandomEffTox",
    "Reoptimize",
    "Reoptimize1",
    "ReturnMeanControl",
    "ReturnMeansAgent",
    "ReturnOCS",
    "RunAdaptiveEffToxTrial",
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    "SimPhase3"
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    {
      "page": "AssignEffTox",
      "title": "Determines the optimal dose to assign the next patient cohort.",
      "topics": [
        "AssignEffTox"
      ]
    },
    {
      "page": "EFFTOX",
      "title": "Obtains estimated posterior probabilities of the four outcomes of (YE,YT) for each dose.",
      "topics": [
        "EFFTOX"
      ]
    },
    {
      "page": "PieceMCMC",
      "title": "Returns posterior distribution for key mixture model parameters",
      "topics": [
        "PieceMCMC"
      ]
    },
    {
      "page": "RandomEffTox",
      "title": "Randomizes Eff-Tox dose proportional to posterior desireability scores.",
      "topics": [
        "RandomEffTox"
      ]
    },
    {
      "page": "Reoptimize",
      "title": "Gives the Optimal Dose for enrolling next patient cohort.",
      "topics": [
        "Reoptimize"
      ]
    },
    {
      "page": "Reoptimize1",
      "title": "Gives the Optimal Dose for enrolling next patient cohort. Used in the SimPhase123 function.",
      "topics": [
        "Reoptimize1"
      ]
    },
    {
      "page": "ReturnMeanControl",
      "title": "Gives true mean survival times for the control therapy.",
      "topics": [
        "ReturnMeanControl"
      ]
    },
    {
      "page": "ReturnMeansAgent",
      "title": "Gives true mean survival times for doses considered of the experimental agent.",
      "topics": [
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      ]
    },
    {
      "page": "ReturnOCS",
      "title": "Gives operating characteristics of phase 123 and conventional design.",
      "topics": [
        "ReturnOCS"
      ]
    },
    {
      "page": "RunAdaptiveEffToxTrial",
      "title": "Simulates repitions of an Adaptive Eff-Tox Trial.",
      "topics": [
        "RunAdaptiveEffToxTrial"
      ]
    },
    {
      "page": "SimPhase123",
      "title": "Simulates replications of the phase123 and phase 12-3 trials.",
      "topics": [
        "SimPhase123"
      ]
    },
    {
      "page": "SimPhase3",
      "title": "Performs one replication of phase 3 for the phase 123 design, given phase 12 data.",
      "topics": [
        "SimPhase3"
      ]
    }
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