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  "Title": "Melt Curve Fitting and Melt Shift Analysis",
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  "Description": "Analyzes raw abundance data from a cellular thermal shift\nexperiment and calculates melt temperatures and melt shifts for\neach protein in the experiment. McCracken (2022)\n<doi:10.1101/2022.12.30.522131>.",
  "License": "GPL-2",
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  "Config/testthat/edition": "3",
  "Author": "Neil McCracken [aut], Hao Liu [ctb], Amber Mosley [cre]",
  "Maintainer": "Amber Mosley <almosley@iu.edu>",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2023-04-19 07:00:03 UTC",
  "RemoteUrl": "https://github.com/cran/InflectSSP",
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  "MD5sum": "5b3698cd1841bd6b1d331b41db7b1471",
  "_user": "cran",
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  "_topics": [
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    "extra/citation.html",
    "extra/citation.json",
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    },
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      "version": "1.4.4",
      "date": "2022-03-18"
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    {
      "version": "1.4.5",
      "date": "2022-10-04"
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      "date": "2023-02-03"
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    "CurveFit2",
    "Import",
    "InflectSSP",
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    "Normalize",
    "Quantify",
    "ReportDataMelts",
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  ],
  "_help": [
    {
      "page": "Correction",
      "title": "This function corrects the normalized abundance of each protein using a correction constant that is calculated in this function. The correction constant is determined using the difference between actual and predicted fit at the proteome level.",
      "topics": [
        "Correction"
      ]
    },
    {
      "page": "CurveFit1",
      "title": "This function determines the 4 parameter or 3 parameter log fit for the proteome level curve.",
      "topics": [
        "CurveFit1"
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    },
    {
      "page": "CurveFit2",
      "title": "This function determines the best curve fit for each protein using the data post correction and also determines the R squared for each curve fit",
      "topics": [
        "CurveFit2"
      ]
    },
    {
      "page": "Import",
      "title": "This function imports data that will be analyzed in downstream functions.",
      "topics": [
        "Import"
      ]
    },
    {
      "page": "InflectSSP",
      "title": "This function is the primary function that calls other functions in the program.",
      "topics": [
        "InflectSSP"
      ]
    },
    {
      "page": "MeltCalc",
      "title": "This function determines melt shifts for all proteins that meet quality criteria and also determines the melt shift p-values",
      "topics": [
        "MeltCalc"
      ]
    },
    {
      "page": "Normalize",
      "title": "This function normalizes the abundance values to that measured at the lowest temperature",
      "topics": [
        "Normalize"
      ]
    },
    {
      "page": "Quantify",
      "title": "This function determines the median abundance value across the proteome for all experiments together",
      "topics": [
        "Quantify"
      ]
    },
    {
      "page": "ReportDataMelts",
      "title": "This function generates results from the Inflect function after applying criteria input from the user",
      "topics": [
        "ReportDataMelts"
      ]
    },
    {
      "page": "ReportSTRING",
      "title": "This function generates a STRING based network using the significant melt shifts from analysis",
      "topics": [
        "ReportSTRING"
      ]
    }
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  ],
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      "source": "InflectSSPVignette.Rmd",
      "filename": "InflectSSPVignette.html",
      "title": "InflectSSPVignette",
      "author": "Neil McCracken",
      "engine": "knitr::rmarkdown",
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        "Introduction",
        "Program inputs",
        "Program outputs",
        "General program analysis description",
        "Example code for execution of the function"
      ],
      "created": "2021-12-16 09:12:12",
      "modified": "2023-02-03 12:32:31",
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  "_indexed": true,
  "_nocasepkg": "inflectssp",
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