{ "_id": "6a27d8c424555f66ed546fd6", "Package": "HDMT", "Type": "Package", "Title": "A Multiple Testing Procedure for High-Dimensional Mediation\nHypotheses", "Version": "1.0.5", "Date": "2022-01-24", "Authors@R": "c(person(\"James\", \"Dai\", role = c(\"aut\", \"cre\"),\nemail = \"jdai@fredhutch.org\"),\nperson(\"Xiaoyu\", \"Wang\", role = c(\"aut\")))", "Author": "James Dai [aut, cre], Xiaoyu Wang [aut]", "Maintainer": "James Dai ", "Description": "A multiple-testing procedure for high-dimensional\nmediation hypotheses. Mediation analysis is of rising interest\nin epidemiology and clinical trials. Among existing methods for\nmediation analyses, the popular joint significance (JS) test\nyields an overly conservative type I error rate and therefore\nlow power. In the R package 'HDMT' we implement a\nmultiple-testing procedure that accurately controls the\nfamily-wise error rate (FWER) and the false discovery rate\n(FDR) when using JS for testing high-dimensional mediation\nhypotheses. The core of our procedure is based on estimating\nthe proportions of three component null hypotheses and deriving\nthe corresponding mixture distribution of null p-values.\nResults of the data examples include better-behaved\nquantile-quantile plots and improved detection of novel\nmediation relationships on the role of DNA methylation in\ngenetic regulation of gene expression. With increasing interest\nin mediation by molecular intermediaries such as gene\nexpression, the proposed method addresses an unmet\nmethodological challenge. Methods used in the package refer to\nJames Y. Dai, Janet L. Stanford & Michael LeBlanc (2020)\n.", "LazyLoad": "no", "License": "MIT + file LICENSE", "NeedsCompilation": "no", "biocViews": "", "Packaged": { "Date": "2026-06-09 09:08:47 UTC", "User": "root" }, "VignetteBuilder": "knitr", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2022-01-29 18:00:02 UTC", "RemoteUrl": "https://github.com/cran/HDMT", "RemoteRef": "HEAD", "RemoteSha": "c142c822ca1d5f055df231da3d58e05cc32fd7d2", "MD5sum": "92ce759481e9635811fbc0b62f6ab204", "_user": "cran", "_type": "src", "_file": "HDMT_1.0.5.tar.gz", "_fileid": "0f861363024172f400cfb4cd5b856b2fcd2807213ef0c0578ffc11158e9d9f63", "_filesize": 2206247, "_sha256": "0f861363024172f400cfb4cd5b856b2fcd2807213ef0c0578ffc11158e9d9f63", "_created": "2026-06-09T09:08:47.000Z", "_published": "2026-06-09T09:11:32.022Z", "_distro": "noble", "_jobs": [ { "job": 80287273763, "time": 130, "config": "linux-devel-x86_64", "r": "4.7.0", "check": "OK", "artifact": "7503342673" }, { "job": 80287273813, "time": 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