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  "Package": "GRAPE",
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  "Title": "Gene-Ranking Analysis of Pathway Expression",
  "Version": "0.1.1",
  "Author": "Michael Klein <michael.klein@yale.edu>",
  "Maintainer": "Michael Klein <michael.klein@yale.edu>",
  "Description": "Gene-Ranking Analysis of Pathway Expression (GRAPE) is a\ntool for summarizing the consensus behavior of biological\npathways in the form of a template, and for quantifying the\nextent to which individual samples deviate from the template.\nGRAPE templates are based only on the relative rankings of the\ngenes within the pathway and can be used for classification of\ntissue types or disease subtypes. GRAPE can be used to\nrepresent gene-expression samples as vectors of pathway scores,\nwhere each pathway score indicates the departure from a given\ncollection of reference samples. The resulting pathway- space\nrepresentation can be used as the feature set for various\napplications, including survival analysis and drug-response\nprediction. Users of GRAPE should use the following citation:\nKlein MI, Stern DF, and Zhao H. GRAPE: A pathway template\nmethod to characterize tissue-specific functionality from gene\nexpression profiles. BMC Bioinformatics, 18:317 (June 2017).",
  "License": "GPL-2",
  "RoxygenNote": "6.1.1",
  "NeedsCompilation": "no",
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    "User": "root"
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  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2019-05-07 21:12:24 UTC",
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    "message": "version 0.1.1\n",
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  "_assets": [
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    "extra/citation.html",
    "extra/citation.json",
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    "getPathwayScores",
    "makeBinaryTemplateAndProbabilityTemplate",
    "makeGRAPE_psMat",
    "makePairwiseOrder",
    "makePairwiseOrderNames",
    "predictClassDIRAC",
    "predictClassGRAPE",
    "predictClassPC",
    "w_quad"
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  "_help": [
    {
      "page": "getPathwayScores",
      "title": "Calculate Pathway Scores",
      "topics": [
        "getPathwayScores"
      ]
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      "page": "makeBinaryTemplateAndProbabilityTemplate",
      "title": "Make binary template and probability template",
      "topics": [
        "makeBinaryTemplateAndProbabilityTemplate"
      ]
    },
    {
      "page": "makeGRAPE_psMat",
      "title": "Calculate Pathway Space Matrix",
      "topics": [
        "makeGRAPE_psMat"
      ]
    },
    {
      "page": "makePairwiseOrder",
      "title": "Make pairwise order representation of a sample",
      "topics": [
        "makePairwiseOrder"
      ]
    },
    {
      "page": "makePairwiseOrderNames",
      "title": "Make template names from gene names",
      "topics": [
        "makePairwiseOrderNames"
      ]
    },
    {
      "page": "predictClassDIRAC",
      "title": "DIRAC Classification",
      "topics": [
        "predictClassDIRAC"
      ]
    },
    {
      "page": "predictClassGRAPE",
      "title": "GRAPE Classification",
      "topics": [
        "predictClassGRAPE"
      ]
    },
    {
      "page": "predictClassPC",
      "title": "PC Classification",
      "topics": [
        "predictClassPC"
      ]
    },
    {
      "page": "w_quad",
      "title": "Quadratic weight function",
      "topics": [
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      ]
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  "_nocasepkg": "grape",
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