{
  "_id": "6a101845acfb0bcc41c855b6",
  "Package": "FamEvent",
  "Type": "Package",
  "Title": "Family Age-at-Onset Data Simulation and Penetrance Estimation",
  "Version": "3.3",
  "Date": "2026-05-14",
  "Authors@R": "c(\nperson(given = \"Yun-Hee\",\nfamily = \"Choi\",\nrole = c(\"aut\", \"cre\"),\nemail = \"yun-hee.choi@schulich.uwo.ca\"),\nperson(given = \"Karen\",\nfamily = \"Kopciuk\",\nrole = \"aut\"),\nperson(given = \"Wenqing\",\nfamily = \"He\",\nrole = \"aut\"),\nperson(given = \"Laurent\",\nfamily = \"Briollais\",\nrole = \"aut\"))",
  "Description": "Simulates age-at-onset traits associated with a\nsegregating major gene in family data obtained from\npopulation-based, clinic-based, or multi-stage designs.\nAppropriate ascertainment correction is utilized to estimate\nage-dependent penetrance functions either parametrically from\nthe fitted model or nonparametrically from the data. The\nExpectation and Maximization algorithm can infer missing\ngenotypes and carrier probabilities estimated from family's\ngenotype and phenotype information or from fitted models. Plot\nfunctions include pedigrees of simulated families and predicted\npenetrance curves based on specified parameter values. For more\ninformation see Choi, Y.-H., Briollais, L., He, W. and Kopciuk,\nK. (2021) FamEvent: An R Package for Generating and Modeling\nTime-to-Event Data in Family Designs, Journal of Statistical\nSoftware 97 (7), 1-30.",
  "License": "GPL (>= 2)",
  "Encoding": "UTF-8",
  "LazyData": "true",
  "NeedsCompilation": "no",
  "URL": "https://CRAN.R-project.org/package=FamEvent",
  "Packaged": {
    "Date": "2026-05-14 23:58:51 UTC",
    "User": "root"
  },
  "Author": "Yun-Hee Choi [aut, cre], Karen Kopciuk [aut], Wenqing He [aut],\nLaurent Briollais [aut]",
  "Maintainer": "Yun-Hee Choi <yun-hee.choi@schulich.uwo.ca>",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2026-05-14 23:14:09 UTC",
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    "author": "Yun-Hee Choi <yun-hee.choi@schulich.uwo.ca>",
    "committer": "cran-robot <csardi.gabor+cran@gmail.com>",
    "message": "version 3.3\n",
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    "description": "Unofficial read-only mirror of all CRAN R packages"
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    "source": "https://cranlogs.r-pkg.org/downloads/total/last-month/FamEvent"
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  "_rbuild": "4.6.0",
  "_assets": [
    "extra/citation.cff",
    "extra/citation.html",
    "extra/citation.json",
    "extra/citation.txt",
    "extra/contents.json",
    "extra/FamEvent.html",
    "manual.pdf"
  ],
  "_realowner": "cran",
  "_cranurl": false,
  "_releases": [
    {
      "version": "1.0",
      "date": "2016-02-09"
    },
    {
      "version": "1.1",
      "date": "2016-03-09"
    },
    {
      "version": "1.2",
      "date": "2016-10-03"
    },
    {
      "version": "1.3",
      "date": "2017-03-26"
    },
    {
      "version": "2.0",
      "date": "2019-03-21"
    },
    {
      "version": "2.1",
      "date": "2021-03-17"
    },
    {
      "version": "3.0",
      "date": "2022-11-17"
    },
    {
      "version": "3.1",
      "date": "2024-04-04"
    },
    {
      "version": "3.2",
      "date": "2024-07-02"
    },
    {
      "version": "3.3",
      "date": "2026-05-14"
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  "_exports": [
    "carrierprob",
    "fampower",
    "penetrance",
    "penetrance_cmp",
    "penmodel",
    "penmodel_cmp",
    "penmodelEM",
    "penplot",
    "penplot_cmp",
    "plot.penmodel",
    "plot.penmodel_cmp",
    "plot.simfam",
    "plot.simfam_cmp",
    "plot.simfam_tvc",
    "plot.simfam2",
    "print.penmodel",
    "print.penmodel_cmp",
    "print.summary.penmodel",
    "print.summary.penmodel_cmp",
    "simfam",
    "simfam_cmp",
    "simfam_tvc",
    "simfam2",
    "summary.penmodel",
    "summary.penmodel_cmp",
    "summary.simfam",
    "summary.simfam_cmp",
    "summary.simfam_tvc",
    "summary.simfam2"
  ],
  "_datasets": [
    {
      "name": "LSfam",
      "title": "Ontario Lynch Syndrom families",
      "object": "LSfam",
      "class": [
        "data.frame"
      ],
      "fields": [
        "famID",
        "indID",
        "fatherID",
        "motherID",
        "gender",
        "status",
        "time",
        "currentage",
        "mgene",
        "proband",
        "relation"
      ],
      "rows": 765,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "FamEvent-package",
      "title": "Family age-at-onset data simulation and penetrance estimation",
      "topics": [
        "FamEvent-package"
      ]
    },
    {
      "page": "carrierprob",
      "title": "Compute mutation carrier probabilities for individuals with missing gentoypes",
      "topics": [
        "carrierprob"
      ]
    },
    {
      "page": "fampower",
      "title": "Simulation-based power calculation for genetic effect",
      "topics": [
        "fampower"
      ]
    },
    {
      "page": "LSfam",
      "title": "Ontario Lynch Syndrom families",
      "topics": [
        "LSfam"
      ]
    },
    {
      "page": "penetrance",
      "title": "Penetrance function and confidence intervals",
      "topics": [
        "penetrance"
      ]
    },
    {
      "page": "penetrance_cmp",
      "title": "Penetrance function for competing risk models and confidence intervals",
      "topics": [
        "penetrance_cmp"
      ]
    },
    {
      "page": "penmodel",
      "title": "Fit a penetrance model",
      "topics": [
        "penmodel"
      ]
    },
    {
      "page": "penmodel_cmp",
      "title": "Fit a penetrance model for competing risks data",
      "topics": [
        "penmodel_cmp"
      ]
    },
    {
      "page": "penmodelEM",
      "title": "EM algorithm for estimating the penetrance model with missing genotypes",
      "topics": [
        "penmodelEM"
      ]
    },
    {
      "page": "penplot",
      "title": "Plot penetrance functions",
      "topics": [
        "penplot"
      ]
    },
    {
      "page": "penplot_cmp",
      "title": "Plot penetrance functions from competing risk models",
      "topics": [
        "penplot_cmp"
      ]
    },
    {
      "page": "plot.penmodel",
      "title": "Plot method for 'penmodel'",
      "topics": [
        "plot.penmodel"
      ]
    },
    {
      "page": "plot.penmodel_cmp",
      "title": "Plot method for 'penmodel_cmp'",
      "topics": [
        "plot.penmodel_cmp"
      ]
    },
    {
      "page": "plot.simfam",
      "title": "Plot method for 'simfam' or Plot pedigrees",
      "topics": [
        "plot.simfam"
      ]
    },
    {
      "page": "plot.simfam_cmp",
      "title": "Plot method for 'simfam_cmp' or Plot pedigrees",
      "topics": [
        "plot.simfam_cmp"
      ]
    },
    {
      "page": "plot.simfam_tvc",
      "title": "Plot method for 'simfam_tvc' or Plot pedigrees",
      "topics": [
        "plot.simfam_tvc"
      ]
    },
    {
      "page": "plot.simfam2",
      "title": "Plot method for 'simfam2' or Plot pedigrees",
      "topics": [
        "plot.simfam2"
      ]
    },
    {
      "page": "print.penmodel",
      "title": "Print method for 'penmodel'.",
      "topics": [
        "print.penmodel"
      ]
    },
    {
      "page": "print.penmodel_cmp",
      "title": "Print method for 'penmodel_cmp'.",
      "topics": [
        "print.penmodel_cmp"
      ]
    },
    {
      "page": "print.summary.penmodel",
      "title": "Print method for 'summary.penmodel' of a fitted penetrance model.",
      "topics": [
        "print.summary.penmodel"
      ]
    },
    {
      "page": "print.summary.penmodel_cmp",
      "title": "Print method for 'summary.penmodel_cmp' of a fitted competing risks penetrance model.",
      "topics": [
        "print.summary.penmodel_cmp"
      ]
    },
    {
      "page": "simfam",
      "title": "Generate familial time-to-event data",
      "topics": [
        "simfam"
      ]
    },
    {
      "page": "simfam_cmp",
      "title": "Generate familial competing risks data",
      "topics": [
        "simfam_cmp"
      ]
    },
    {
      "page": "simfam_tvc",
      "title": "Generate familial time-to-event data with a time-varying covariate",
      "topics": [
        "simfam_tvc"
      ]
    },
    {
      "page": "simfam2",
      "title": "Generate familial time-to-event data with Kinship or IBD matrices.",
      "topics": [
        "simfam2"
      ]
    },
    {
      "page": "summary.penmodel",
      "title": "Summary method for class 'penmodel'",
      "topics": [
        "summary.penmodel"
      ]
    },
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      "page": "summary.penmodel_cmp",
      "title": "Summary method for class 'penmodel_cmp'",
      "topics": [
        "summary.penmodel_cmp"
      ]
    },
    {
      "page": "summary.simfam",
      "title": "Summary method for 'simfam'",
      "topics": [
        "summary.simfam"
      ]
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      "title": "Summary method for 'simfam_cmp'",
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        "summary.simfam_cmp"
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      "title": "Summary method for 'simfam_tvc'",
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        "summary.simfam_tvc"
      ]
    },
    {
      "page": "summary.simfam2",
      "title": "Summary method for 'simfam2'",
      "topics": [
        "summary.simfam2"
      ]
    }
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