{ "_id": "6a1d5b151d7bb097a0a48737", "Package": "CFO", "Title": "CFO-Type Designs in Phase I/II Clinical Trials", "Version": "2.2.0", "Authors@R": "c(\nperson(\"Jialu\", \"Fang\", email =\"u3008682@connect.hku.hk\", role = c(\"aut\", \"cre\")),\nperson(\"Ninghao\", \"Zhang\", email =\"zhangnh421@connect.hku.hk\", role = \"aut\"),\nperson(\"Wenliang\", \"Wang\", email =\"wangwl@connect.hku.hk\", role = \"aut\"),\nperson(\"Guosheng\", \"Yin\", email =\"gyin@hku.hk\", role = \"aut\"))", "Description": "In phase I clinical trials, the primary objective is to\nascertain the maximum tolerated dose (MTD) corresponding to a\nspecified target toxicity rate. The subsequent phase II trials\nare designed to examine the potential efficacy of the drug\nbased on the MTD obtained from the phase I trials, with the aim\nof identifying the optimal biological dose (OBD). The 'CFO'\npackage facilitates the implementation of dose-finding trials\nby utilizing calibration-free odds type (CFO-type) designs.\nSpecifically, it encompasses the calibration-free odds (CFO)\n(Jin and Yin (2022) ),\nrandomized CFO (rCFO), precision CFO (pCFO), two-dimensional\nCFO (2dCFO) (Wang et al. (2023)\n), time-to-event CFO (TITE-CFO)\n(Jin and Yin (2023) ), fractional CFO\n(fCFO), accumulative CFO (aCFO), TITE-aCFO, and f-aCFO (Fang\nand Yin (2024) ). It supports phase\nI/II trials for the CFO design and only phase I trials for the\nother CFO-type designs. The ‘CFO' package accommodates diverse\nCFO-type designs, allowing users to tailor the approach based\non factors such as dose information inclusion, handling of\nlate-onset toxicity, and the nature of the target drug\n(single-drug or drug-combination). The functionalities embedded\nin 'CFO' package include the determination of the dose level\nfor the next cohort, the selection of the MTD for a real trial,\nand the execution of single or multiple simulations to obtain\noperating characteristics. Moreover, these functions are\nequipped with early stopping and dose elimination rules to\naddress safety considerations. Users have the flexibility to\nchoose different distributions, thresholds, and cohort sizes\namong others for their specific needs. The output of the 'CFO'\npackage can be summary statistics as well as various plots for\nbetter visualization. An interactive web application for CFO is\navailable at the provided URL.", "License": "GPL-2", "URL": "https://clinicaltrialdesign.shinyapps.io/cfoapp", "Encoding": "UTF-8", "RoxygenNote": "7.3.2", "NeedsCompilation": "no", "Packaged": { "Date": "2026-06-01 10:08:56 UTC", "User": "root" }, "Author": "Jialu Fang [aut, cre], Ninghao Zhang [aut], Wenliang Wang\n[aut], Guosheng Yin [aut]", "Maintainer": "Jialu Fang ", "Repository": "https://cran.r-universe.dev", "Date/Publication": "2024-11-15 12:00:09 UTC", "RemoteUrl": "https://github.com/cran/CFO", "RemoteRef": "HEAD", "RemoteSha": "64f35b5896273e2a146792e9f2c5ac0f4f46f73d", "MD5sum": "b6c4c100a8ba64daa3743ad3a7b675eb", "_user": "cran", "_type": "src", "_file": "CFO_2.2.0.tar.gz", "_fileid": "3717d21896ea587216ba75716010f9bc34a5f072f8b1e86b9cd13c39d3deb018", "_filesize": 352143, "_sha256": "3717d21896ea587216ba75716010f9bc34a5f072f8b1e86b9cd13c39d3deb018", "_created": "2026-06-01T10:08:56.000Z", "_published": 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