{
  "_id": "6a1db8cd1d7bb097a0a52fab",
  "Package": "BuyseTest",
  "Type": "Package",
  "Title": "Generalized Pairwise Comparisons",
  "Version": "3.3.9",
  "Date": "2026-06-01",
  "Authors@R": "c(\nperson(\"Brice\", \"Ozenne\", role = c(\"aut\", \"cre\"), email = \"brice.mh.ozenne@gmail.com\", comment = c(ORCID = \"0000-0001-9694-2956\")),\nperson(\"Eva\", \"Cantagallo\", role = \"aut\"),\nperson(\"William\", \"Anderson\", role = \"aut\"),\nperson(\"Julien\", \"Peron\", role = \"ctb\"),\nperson(\"Johan\", \"Verbeeck\", role = \"ctb\")\n)",
  "Description": "Implementation of the Generalized Pairwise Comparisons\n(GPC) as defined in Buyse (2010) <doi:10.1002/sim.3923> for\ncomplete observations, and extended in Peron (2018)\n<doi:10.1177/0962280216658320> to deal with right-censoring.\nGPC compare two groups of observations (intervention vs.\ncontrol group) regarding several prioritized endpoints to\nestimate the probability that a random observation drawn from\none group performs better/worse/equivalently than a random\nobservation drawn from the other group. Summary statistics such\nas the net treatment benefit, win ratio, or win odds are then\ndeduced from these probabilities. Confidence intervals and\np-values are obtained based on asymptotic results (Ozenne 2021\n<doi:10.1177/09622802211037067>), non-parametric bootstrap, or\npermutations. The software enables the use of thresholds of\nminimal importance difference, stratification, non-prioritized\nendpoints (O Brien test), and can handle right-censoring and\ncompeting-risks.",
  "License": "GPL-3",
  "Encoding": "UTF-8",
  "URL": "https://github.com/bozenne/BuyseTest",
  "BugReports": "https://github.com/bozenne/BuyseTest/issues",
  "VignetteBuilder": "R.rsp",
  "NeedsCompilation": "yes",
  "RoxygenNote": "7.3.3",
  "Collate": "'0-onLoad.R' '1-setGeneric.R' 'BuyseMultComp.R' 'BuyseTTEM.R'\n'BuyseTest-Peron.R' 'BuyseTest-check.R' 'BuyseTest-inference.R'\n'BuyseTest-initialization.R' 'BuyseTest-package.R'\n'BuyseTest-print.R' 'BuyseTest.R' 'BuyseTest.options.R'\n'CasinoTest.R' 'PairScore.R' 'RcppExports.R' 'S4-BuysePower.R'\n'S4-BuysePower-model.tables.R' 'S4-BuysePower-nobs.R'\n'S4-BuysePower-summary.R' 'S4-BuysePower-print.R'\n'S4-BuysePower-show.R' 'S4-BuyseTest.R' 'S4-BuyseTest-coef.R'\n'S4-BuyseTest-confint.R' 'S4-BuyseTest-get.R'\n'S4-BuyseTest-model.tables.R' 'S4-BuyseTest-nobs.R'\n'S4-BuyseTest-plot.R' 'S4-BuyseTest-summary.R'\n'S4-BuyseTest-print.R' 'S4-BuyseTest-sensitivity.R'\n'S4-BuyseTest-show.R' 'S4-BuyseTest-update.R'\n'S4-BuyseTest.options.R' 'S4-BuyseTest.vcov.R'\n'as.data.table.performance.R' 'auc.R' 'autoplot.S4BuyseTest.R'\n'brier.R' 'constStrata.R' 'discreteRoot.R' 'doc-data.R'\n'efronlim.R' 'iid.S3sensitivity.R' 'iid.prodlim.R' 'mover.R'\n'normexp.R' 'performance.R' 'performanceResample.R'\n'plot.S3sensitivity.R' 'powerBuyseTest.R' 'predict.logit.R'\n'rbind.performanceResample.R' 'sim.simBuyseTest.R'\n'simBuyseTest.R' 'simCompetingRisks.R' 'summary.performance.R'\n'valid.R'",
  "Packaged": {
    "Date": "2026-06-01 16:45:10 UTC",
    "User": "root"
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  "Author": "Brice Ozenne [aut, cre] (ORCID:\n<https://orcid.org/0000-0001-9694-2956>), Eva Cantagallo [aut],\nWilliam Anderson [aut], Julien Peron [ctb], Johan Verbeeck\n[ctb]",
  "Maintainer": "Brice Ozenne <brice.mh.ozenne@gmail.com>",
  "Repository": "https://cran.r-universe.dev",
  "Date/Publication": "2026-06-01 10:50:02 UTC",
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    "powerBuyseTest",
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    "summary",
    "update",
    "vcov"
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      "tojson": true
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      "title": "RCT In Metastatic Pancreatic Cancer Comparing Two Chemoterapy.",
      "object": "prodige",
      "file": "prodige.rda",
      "class": [
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        "data.frame"
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  "_help": [
    {
      "page": "BuyseTest-package",
      "title": "BuyseTest package: Generalized Pairwise Comparisons",
      "topics": [
        "BuyseTest-package"
      ]
    },
    {
      "page": "dot-colCenter_cpp",
      "title": "Substract a vector of values in each column",
      "topics": [
        ".colCenter_cpp"
      ]
    },
    {
      "page": "dot-colCumSum_cpp",
      "title": "Column-wise cumulative sum",
      "topics": [
        ".colCumSum_cpp"
      ]
    },
    {
      "page": "dot-colMultiply_cpp",
      "title": "Multiply by a vector of values in each column",
      "topics": [
        ".colMultiply_cpp"
      ]
    },
    {
      "page": "dot-colScale_cpp",
      "title": "Divide by a vector of values in each column",
      "topics": [
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      ]
    },
    {
      "page": "dot-rowCenter_cpp",
      "title": "Substract a vector of values in each row",
      "topics": [
        ".rowCenter_cpp"
      ]
    },
    {
      "page": "dot-rowCumProd_cpp",
      "title": "Apply cumprod in each row",
      "topics": [
        ".rowCumProd_cpp"
      ]
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    {
      "page": "dot-rowCumSum_cpp",
      "title": "Row-wise cumulative sum",
      "topics": [
        ".rowCumSum_cpp"
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    {
      "page": "dot-rowMultiply_cpp",
      "title": "Multiply by a vector of values in each row",
      "topics": [
        ".rowMultiply_cpp"
      ]
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    {
      "page": "dot-rowScale_cpp",
      "title": "Dividy by a vector of values in each row",
      "topics": [
        ".rowScale_cpp"
      ]
    },
    {
      "page": "as.data.table.performance",
      "title": "Convert Performance Objet to data.table",
      "topics": [
        "as.data.table.performance"
      ]
    },
    {
      "page": "auc",
      "title": "Estimation of the Area Under the ROC Curve (EXPERIMENTAL)",
      "topics": [
        "auc"
      ]
    },
    {
      "page": "autoplot-S4BuyseTest",
      "title": "Graphical Display for GPC",
      "topics": [
        "autoplot.S4BuyseTest"
      ]
    },
    {
      "page": "brier",
      "title": "Estimation of the Brier Score (EXPERIMENTAL)",
      "topics": [
        "brier"
      ]
    },
    {
      "page": "BuyseMultComp",
      "title": "Adjustment for Multiple Comparisons",
      "topics": [
        "BuyseMultComp"
      ]
    },
    {
      "page": "BuyseTest",
      "title": "Two-group GPC",
      "topics": [
        "BuyseTest"
      ]
    },
    {
      "page": "BuyseTest.options",
      "title": "Global options for BuyseTest package",
      "topics": [
        "BuyseTest.options"
      ]
    },
    {
      "page": "BuyseTest.options-class",
      "title": "Class \"BuyseTest.options\" (global setting for the BuyseTest package)",
      "topics": [
        "BuyseTest.options-class"
      ]
    },
    {
      "page": "BuyseTest.options-methods",
      "title": "Methods for the class \"BuyseTest.options\"",
      "topics": [
        "alloc,BuyseTest.options-method",
        "BuyseTest.options-methods",
        "select,BuyseTest.options-method"
      ]
    },
    {
      "page": "BuyseTTEM",
      "title": "Time to Event Model",
      "topics": [
        "BuyseTTEM",
        "BuyseTTEM.BuyseTTEM",
        "BuyseTTEM.formula",
        "BuyseTTEM.prodlim",
        "BuyseTTEM.survreg"
      ]
    },
    {
      "page": "CasinoTest",
      "title": "Multi-group GPC (EXPERIMENTAL)",
      "topics": [
        "CasinoTest"
      ]
    },
    {
      "page": "data-CHARM",
      "title": "RCT In Chronic Heart Failure Assessing an Inhibitor of the Renin-Angiotensin System.",
      "topics": [
        "CHARM"
      ]
    },
    {
      "page": "coef.BuyseTestAuc",
      "title": "Extract the AUC Value",
      "topics": [
        "coef.BuyseTestAuc"
      ]
    },
    {
      "page": "coef.BuyseTestBrier",
      "title": "Extract the Brier Score",
      "topics": [
        "coef.BuyseTestBrier"
      ]
    },
    {
      "page": "confint.BuyseTestAuc",
      "title": "Extract the AUC value with its Confidence Interval",
      "topics": [
        "confint.BuyseTestAuc"
      ]
    },
    {
      "page": "confint.BuyseTestBrier",
      "title": "Extract the Brier Score with its Confidence Interval",
      "topics": [
        "confint.BuyseTestBrier"
      ]
    },
    {
      "page": "constStrata",
      "title": "Strata creation",
      "topics": [
        "constStrata"
      ]
    },
    {
      "page": "data-EB",
      "title": "Rare disease trial",
      "topics": [
        "EB"
      ]
    },
    {
      "page": "efronlim",
      "title": "Constrained Kaplan-Meier Estimator",
      "topics": [
        "efronlim"
      ]
    },
    {
      "page": "getCount",
      "title": "Extract the Number of Favorable, Unfavorable, Neutral, Uninformative pairs",
      "topics": [
        "getCount",
        "getCount,S4BuyseTest-method"
      ]
    },
    {
      "page": "getIid",
      "title": "Extract the H-decomposition of the Estimator",
      "topics": [
        "getIid",
        "getIid,S4BuyseTest-method"
      ]
    },
    {
      "page": "getMatrixScore",
      "title": "Extract the Score Matrix",
      "topics": [
        "getMatrixScore",
        "getMatrixScore,S4BuyseTest-method"
      ]
    },
    {
      "page": "getPairScore",
      "title": "Extract the Score of Each Pair",
      "topics": [
        "getPairScore",
        "getPairScore,S4BuyseTest-method"
      ]
    },
    {
      "page": "getPseudovalue",
      "title": "Extract the pseudovalues of the Estimator",
      "topics": [
        "getPseudovalue",
        "getPseudovalue,S4BuyseTest-method"
      ]
    },
    {
      "page": "getSurvival",
      "title": "Extract the Survival and Survival Jumps",
      "topics": [
        "getSurvival",
        "getSurvival,S4BuyseTest-method"
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