Package: ReAD
Type: Package
Title: Powerful Replicability Analysis of Genome-Wide Association
        Studies
Version: 1.0.1
Authors@R: c(person("Yan Li", role = c("aut", "cre", "cph"), email = "yanli_@jlu.edu.cn"), person("Haochen lei", role = c("aut")), person("Xiaoquan Wen", role = c("aut")), person("Hongyuan Cao", role = c("aut")))
Description: A robust and powerful approach is developed for
        replicability analysis of two Genome-wide association studies
        (GWASs) accounting for the linkage disequilibrium (LD) among
        genetic variants. The LD structure in two GWASs is captured by
        a four-state hidden Markov model (HMM). The unknowns involved
        in the HMM are estimated by an efficient
        expectation-maximization (EM) algorithm in combination with a
        non-parametric estimation of functions. By incorporating
        information from adjacent locations via the HMM, this approach
        identifies the entire clusters of genotype-phenotype associated
        signals, improving the power of replicability analysis while
        effectively controlling the false discovery rate.
License: GPL-3
Encoding: UTF-8
Depends: Rcpp (>= 1.0.10), qvalue
LinkingTo: Rcpp, RcppArmadillo
RoxygenNote: 7.2.3
NeedsCompilation: yes
Packaged: 2026-10-06 12:13:07 UTC; root
Author: Yan Li [aut, cre, cph], Haochen lei [aut], Xiaoquan Wen [aut],
        Hongyuan Cao [aut]
Maintainer: Yan Li <yanli_@jlu.edu.cn>
Repository: https://cran.r-universe.dev
Date/Publication: 2023-06-30 10:00:10 UTC
RemoteUrl: https://github.com/cran/ReAD
RemoteRef: HEAD
RemoteSha: ded0a60a7161093e88b4fea75888cf006ae752cf