Package: RNOmni
Title: Rank Normal Transformation Omnibus Test
Version: 1.0.1.2
Date: 2023-09-10
Authors@R: 
    person(
        given = "Zachary",
	family = "McCaw",
	role = c("aut", "cre"),
	email = "zmccaw@alumni.harvard.edu",
	comment = c(ORCID = "0000-0002-2006-9828")
    )
Description: Inverse normal transformation (INT) based genetic
        association testing. These tests are recommend for continuous
        traits with non-normally distributed residuals. INT-based tests
        robustly control the type I error in settings where standard
        linear regression does not, as when the residual distribution
        exhibits excess skew or kurtosis. Moreover, INT-based tests
        outperform standard linear regression in terms of power. These
        tests may be classified into two types. In direct INT (D-INT),
        the phenotype is itself transformed. In indirect INT (I-INT),
        phenotypic residuals are transformed. The omnibus test (O-INT)
        adaptively combines D-INT and I-INT into a single robust and
        statistically powerful approach. See McCaw ZR, Lane JM, Saxena
        R, Redline S, Lin X. "Operating characteristics of the
        rank-based inverse normal transformation for quantitative trait
        analysis in genome-wide association studies"
        <doi:10.1111/biom.13214>.
Depends: R (>= 3.2.2)
Imports: plyr, Rcpp, stats
LinkingTo: Rcpp, RcppArmadillo
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.1.2
Suggests: testthat (>= 3.0.0), withr, R.rsp
VignetteBuilder: R.rsp
Config/testthat/edition: 3
NeedsCompilation: yes
Packaged: 2026-10-28 10:18:39 UTC; root
Author: Zachary McCaw [aut, cre]
        (<https://orcid.org/0000-0002-2006-9828>)
Maintainer: Zachary McCaw <zmccaw@alumni.harvard.edu>
Repository: https://cran.r-universe.dev
Date/Publication: 2023-09-11 06:32:36 UTC
RemoteUrl: https://github.com/cran/RNOmni
RemoteRef: HEAD
RemoteSha: 37586340b6851efe1db503e2157605a16c9dd722