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cff-version: 1.2.0
message: 'To cite package "PoPdesign" in publications use:'
type: software
license: GPL-2.0-only
title: 'PoPdesign: Posterior Predictive (PoP) Design for Phase I Clinical Trials'
version: 1.1.0
identifiers:
- type: doi
  value: 10.32614/CRAN.package.PoPdesign
abstract: The primary goal of phase I clinical trials is to find the maximum tolerated
  dose (MTD). To reach this objective, we introduce a new design for phase I clinical
  trials, the posterior predictive (PoP) design. The PoP design is an innovative model-assisted
  design that is as simply as the conventional algorithmic designs as its decision
  rules can be pre-tabulated prior to the onset of trial, but is of more flexibility
  of selecting diverse target toxicity rates and cohort sizes. The PoP design has
  desirable properties, such as coherence and consistency. Moreover, the PoP design
  provides better empirical performance than the BOIN and Keyboard design with respect
  to high average probabilities of choosing the MTD and slightly lower risk of treating
  patients at subtherapeutic or overly toxic doses.
authors:
- family-names: Fu
  given-names: Chenqi
- family-names: Fang
  given-names: Xinying
  email: xf.research@outlook.com
- family-names: Zhou
  given-names: Shouhao
preferred-citation:
  type: article
  title: Posterior predictive design for phase I clinical trials.
  authors:
  - family-names: Fu
    given-names: Chenqi
  - family-names: Zhou
    given-names: Shouhao
    email: shouhao.zhou@psu.edu
  journal: Manuscript in preparation
  year: '2020'
repository: https://CRAN.R-project.org/package=PoPdesign
date-released: '2024-06-30'
contact:
- family-names: Fang
  given-names: Xinying
  email: xf.research@outlook.com