Package: HybridDesign
Type: Package
Title: Hybrid Design for Phase I Dose-Finding Studies
Version: 1.0
Authors@R: 
    c(person(given = "Heng",
           family = "Zhou",
           role = c("aut", "cre"),
           email = "heng.zhou@merck.com"),
    person(given = "Feng",
           family = "Zhou",
           role = "aut"),
    person(given = "Jason",
           family = "Liao",
           role = "aut"))
Maintainer: Heng Zhou <heng.zhou@merck.com>
Description: The Hybrid design is a combination of model-assisted
        design (e.g., the modified Toxicity Probability Interval
        design) with dose-toxicity model-based design for phase I
        dose-finding studies. The hybrid design controls the overdosing
        toxicity well and leads to a recommended dose closer to the
        true maximum tolerated dose (MTD) due to its ability to
        calibrate for an intermediate dose. More details can be found
        in Liao et al. 2022 <doi:10.1002/ijc.34203>.
Imports: testit, ResourceSelection
Depends: R (>= 3.6)
License: GPL-3
Encoding: UTF-8
RoxygenNote: 7.1.2
NeedsCompilation: no
Packaged: 2026-09-25 08:12:02 UTC; root
Author: Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]
Repository: https://cran.r-universe.dev
Date/Publication: 2022-12-15 08:10:02 UTC
RemoteUrl: https://github.com/cran/HybridDesign
RemoteRef: HEAD
RemoteSha: b65a1a2b36ab27ed51a78a107198fb4b9d4dfe71