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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "HetSeq" in publications use:'
type: software
license: Apache-2.0
title: 'HetSeq: Identifying Modulators of Cellular Responses Leveraging Intercellular
  Heterogeneity'
version: 0.1.0
doi: 10.32614/CRAN.package.HetSeq
abstract: Cellular responses to perturbations are highly heterogeneous and depend
  largely on the initial state of cells. Connecting post-perturbation cells via cellular
  trajectories to untreated cells (e.g. by leveraging metabolic labeling information)
  enables exploitation of intercellular heterogeneity as a combined knock-down and
  overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see
  'Berg et al' <https://doi.org/10.1101/2024.10.28.620481>). This package contains
  functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked
  alkylation of RNA for metabolic labelling sequencing) time courses, functions to
  identify pathway modulators and to visualize the results.
authors:
- family-names: Berg
  given-names: Kevin
  email: Kevin.Berg@informatik.uni-regensburg.de
- family-names: Erhard
  given-names: Florian
  email: Florian.Erhard@informatik.uni-regensburg.de
  orcid: https://orcid.org/0000-0002-3574-6983
- family-names: Sakellaridi
  given-names: Lygeri
  email: Lygeri.Sakellaridi@informatik.uni-regensburg.de
repository: https://CRAN.R-project.org/package=HetSeq
repository-code: https://github.com/erhard-lab/HetSeq
url: https://github.com/erhard-lab/HetSeq
date-released: '2025-02-03'
contact:
- family-names: Berg
  given-names: Kevin
  email: Kevin.Berg@informatik.uni-regensburg.de