Package 'GofCens'

Title: Goodness-of-Fit Methods for Complete and Right-Censored Data
Description: Graphical tools and goodness-of-fit tests for complete and right-censored data: 1. Kolmogorov-Smirnov, Cramér-von Mises, and Anderson-Darling tests, which utilize the empirical distribution function for complete data and are extended to handle right-censored data. 2. Generalized chi-squared-type test, which is based on the squared differences between observed and expected counts using random cells with right-censored data. 3. Graphical tools, such as probability and cumulative hazard plots, to help guide decisions about the most appropriate parametric model for the data.
Authors: Klaus Langohr [aut, cre], Mireia Besalú [aut], Matilde Francisco [aut], Arnau Garcia [aut], Guadalupe Gómez [aut]
Maintainer: Klaus Langohr <[email protected]>
License: GPL (>= 2)
Version: 1.2.1
Built: 2024-11-11 01:23:21 UTC
Source: CRAN

Help Index


Goodness-of-Fit Methods for Complete and Right-Censored Data.

Description

This package provides both graphical tools and goodness-of-fit tests for analyzing complete and right-censored data. It includes:

  1. Kolmogorov-Smirnov, Cramér-von Mises, and Anderson-Darling tests, which utilize the empirical distribution function for complete data and are extended to handle right-censored data.

  2. Generalized chi-squared-type test, which is based on the squared differences between observed and expected counts using random cells with right-censored data.

  3. Graphical tools, such as probability and cumulative hazard plots, to help guide decisions about the most appropriate parametric model for the data.

Details

The GofCens package can be used to assess the goodness of fit for the following eight distributions. The list below displays the parameterizations of their survival functions.

  1. Exponential Distribution [Exp(β)(\beta)]

    S(t)=etβS(t)=e^{-\frac{t}{\beta}}

  2. Weibull Distribution [Wei(α,β\alpha,\,\beta)]

    S(t)=e(tβ)αS(t)=e^{-(\frac{t}{\beta})^\alpha}

  3. Gumbel Distribution [Gum(μ,β\mu,\,\beta)]

    S(t)=1eetμβS(t)=1 - e^{-e^{-\frac{t-\mu}{\beta}}}

  4. Log-Logistic Distribution [LLogis(α,β\alpha, \beta)]

    S(t)=11+(tβ)αS(t)=\frac{1}{1 + \left(\frac{t}{\beta}\right)^\alpha}

  5. Logistic Distribution [Logis(μ,β\mu,\beta)]

    S(t)=etμβ1+etμβS(t)=\frac{e^{-\frac{t -\mu}{\beta}}}{1 + e^{-\frac{t - \mu}{\beta}}}

  6. Log-Normal Distribution [LN(μ,β\mu,\beta)]

    S(t)=logtμβ ⁣12πS(t)=\int_{\frac{\log t - \mu}{\beta}}^\infty \!\frac{1}{\sqrt{2 \pi}}

  7. Normal Distribution [N(μ,β\mu,\beta)]

    S(t)=t ⁣1β2πe(xμ)22β2dxS(t)=\int_t^\infty \! \frac{1}{\beta\sqrt{2\pi}}e^{-\frac{(x - \mu)^2}{2 \beta^2}} dx

  8. 4-Param. Beta Distribution [Beta(α,γ,a,b\alpha, \gamma, a, b)]

    S(t)=1B(α,γ,a,b)(t)B(α,γ)S(t)=1 - \frac{B_{(\alpha, \gamma, a, b)}(t)}{B(\alpha, \gamma)}

The parameters of the theoretical distribution can be set manually using the params0 argument in each function. In this case, the correspondences are as follows: α\alpha represents the shape, γ\gamma the shape2, μ\mu the location, and β\beta the scale parameter.

Package: GofCens
Type: Package
Version: 1.2.1
Date: 2024-11-9
License: GPL (>= 2)

Author(s)

Klaus Langohr, Mireia Besalú, Matilde Francisco, Arnau Garcia, Guadalupe Gómez

Maintainer: Klaus Langohr <[email protected]>


Anderson-Darling test for complete and right-censored data

Description

Function ADcens computes the Anderson-Darling test statistic and p-value for complete and right-censored data against eight possible distributions using bootstrapping.

Usage

## Default S3 method:
ADcens(times, cens = rep(1, length(times)),
       distr = c("exponential", "gumbel", "weibull", "normal",
                 "lognormal", "logistic", "loglogistic", "beta"),
       betaLimits = c(0, 1), igumb = c(10, 10), BS = 999,
       params0 = list(shape = NULL, shape2 = NULL,
                      location = NULL, scale = NULL), tol = 1e-04, ...)
## S3 method for class 'formula'
ADcens(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

BS

Number of bootstrap samples.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

tol

Precision of survival times.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

...

Additional arguments.

Details

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

To avoid long computation times due to bootstrapping, an alternative with complete data is the function ad.test of the goftest package.

The precision of the survival times is important mainly in the data generation step of the bootstrap samples.

Value

ADcens returns an object of class "ADcens".

An object of class "ADcens" is a list containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the Anderson-Darling statistic (AD) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

Warning

If the amount of data is large, the execution time of the function can be elevated. The parameter BS can limit the number of random censored samples generated and reduce the execution time.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

G. Marsaglia and J. Marsaglia. Evaluating the Aderson-Darling Distrinution. In: Journal os Statistical Software, Articles, 9 (2) (2004), 1-5.

See Also

Function ad.test (Package goftest) for complete data and function gofcens for statistics and p-value of the Kolmogorov-Smirnov, Cramér von-Mises and Anderson-Darling together for right-censored data.

Examples

# Complete data
set.seed(123)
ADcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
       BS = 199)
print(ADcens(times = rweibull(100, 12, scale = 4), distr = "exponential",
             BS = 199), outp = "table", print.BIC = FALSE, print.infoBoot = TRUE)

## Not run: 
# Censored data
set.seed(123)
colonsamp <- colon[sample(nrow(colon), 300), ]
ADcens(Surv(time, status) ~ 1, colonsamp, distr = "normal")

## End(Not run)

General chi-squared statistics for right-censored data.

Description

Function chisqcens computes the general chi-squared test statistic for right-censored data introduced by Kim (1993) and the respective p-value using bootstrapping.

Usage

## Default S3 method:
chisqcens(times, cens = rep(1, length(times)), M,
          distr = c("exponential", "gumbel", "weibull", "normal",
                    "lognormal", "logistic", "loglogistic", "beta"),
          betaLimits=c(0, 1), igumb = c(10, 10), BS = 999,
          params0 = list(shape = NULL, shape2 = NULL,
                         location = NULL, scale = NULL), tol = 1e-04, ...)
## S3 method for class 'formula'
chisqcens(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

M

Number indicating the number of cells that will be considered.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

BS

Number of bootstrap samples.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

tol

Precision of survival times.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

...

Additional arguments.

Details

The function implements the test introduced by Kim (1993) and returns the value of the test statistic.

The cell boundaries of the test are obtained via the quantiles, which are based on the Kaplan-Meier estimate of the distribution function. In the presence of right-censored data, it is possible that not all quantiles are estimated, and in this case, the value of M provided by the user is reduced.

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

The precision of the survival times is important mainly in the data generation step of the bootstrap samples.

Value

chisqcens returns an object of class "chisqcens".

An object of class "chisqcens" is a list containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the test statistic (Statistic) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

CellNumber

Vector with two values: the original cell number introduced by the user and the final cell number used.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

J. H. Kim. Chi-Square Goodness-of-Fit Tests for Randomly Censored Data. In: The Annals of Statistics, 21 (3) (1993), 1621-1639.

Examples

# Complete data
set.seed(123)
chisqcens(times = rgumbel(100, 12, scale = 4), M = 8, distr = "gumbel",
          BS = 99)
print(chisqcens(times = rlogis(100, 20, scale = 3), M = 8, distr = "loglogistic",
                BS = 105), print.AIC = FALSE, print.infoBoot = TRUE)

## Not run: 
# Censored data
set.seed(123)
colonsamp <- colon[sample(nrow(colon), 300), ]
chisqcens(Surv(time, status) ~ 1, colonsamp, M = 6, distr = "normal")

## End(Not run)

Cumulative hazard plots to check the goodness of fit of parametric models

Description

Function cumhazPlot uses the cumulative hazard plot to check if a certain distribution is an appropiate choice for the data.

Usage

## Default S3 method:
cumhazPlot(times, cens = rep(1, length(times)), distr = "all6", colour = 1,
           betaLimits = c(0, 1), igumb = c(10, 10), ggp = FALSE, m = NULL,
           prnt = TRUE, degs = 3, print.AIC = TRUE, print.BIC = TRUE, ...)
## S3 method for class 'formula'
cumhazPlot(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the names of the distributions to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution. By default, distr is set to "all6", which means that the cumulative hazard plots are drawn for the Weibull, loglogistic, lognormal, Gumbel, logistic, and normal distributions.

colour

Colour of the points. Default colour: black.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

ggp

Logical to use or not the ggplot2 package to draw the plots. Default is FALSE.

m

Optional layout for the plots to be displayed.

prnt

Logical to indicate if the maximum likelihood estimates of the parameters of all distributions considered should be printed. Default is TRUE.

degs

Integer indicating the number of decimal places of the numeric results of the output.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

...

Optional arguments for function par, if ggplo = FALSE.

Details

The cumulative hazard plot is based on transforming the cumulative hazard function Λ\Lambda in such a way that it becomes linear in tt or log(t)\log(t). This transformation is specific for each distribution. The function uses the data to compute the Nelson-Aalen estimator of the cumulative hazard function, Λ^\widehat{\Lambda}, and the maximum likelihood estimators of the parameters of the theoretical distribution under study. If the distribution fits the data, the plot is expected to be a straight line.

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

Value

If prnt = TRUE, the following output is returned:

Distribution

Distribution under study.

Estimates

A list with the maximum likelihood estimates of the parameters of all distributions considered.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

# Complete data and default distributions
set.seed(123)
x <- rlogis(1000, 50, 5)
cumhazPlot(x, lwd = 2)

# Censored data comparing three distributions
data(nba)
cumhazPlot(Surv(survtime, cens) ~ 1, nba, distr = c("expo", "normal", "gumbel"))

Cramér-von Mises test for complete and right-censored data

Description

Function CvMcens computes the Cramér-von Mises statistic and p-value for complete and right-censored data against eight possible distributions.

Usage

## Default S3 method:
CvMcens(times, cens = rep(1, length(times)),
        distr = c("exponential", "gumbel", "weibull", "normal",
                  "lognormal", "logistic", "loglogistic", "beta"),
        betaLimits = c(0, 1), igumb = c(10, 10), BS = 999,
        params0 = list(shape = NULL, shape2 = NULL,
                       location = NULL, scale = NULL), tol = 1e-04, ...)
## S3 method for class 'formula'
CvMcens(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

BS

Number of bootstrap samples.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

tol

Precision of survival times.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

...

Additional arguments.

Details

Koziol and Green (1976) proposed a Cramér-von Mises statistic for randomly censored data. This function reproduces this test for a given survival data and a theorical distribution. In presence of ties, different authors provide slightly different definitions of the product-limit estimator, what might provide different values of the test statistic.

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

To avoid long computation times due to bootstrapping, an alternative with complete data is the function cvm.test of the goftest package.

The precision of the survival times is important mainly in the data generation step of the bootstrap samples.

Value

CvMcens returns an object of class "CvMcens".

An object of class "CvMcens" is a list containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the Cramér-von Mises statistic (CvM) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

Warning

If the amount of data is large, the execution time of the function can be elevated. The parameter BS can limit the number of random censored samples generated and reduce the execution time.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

J. A. Koziol and S. B. Green. A Cramér-von Mises statistic for randomly censored data. In: Biometrika, 63 (3) (1976), 465-474.

A. N. Pettitt and M. A. Stephens. Modified Cramér-von Mises statistics for censored data. In: Biometrika, 63 (2) (1976), 291-298.

See Also

Function cvm.test (Package goftest) for complete data and gofcens for statistics and p-value of Kolmogorov-Smirnov, Cramér von-Mises and Anderson-Darling together for right-censored data.

Examples

# Complete data
set.seed(123)
CvMcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
        BS = 199)
print(CvMcens(times = rweibull(100, 12, scale = 4), distr = "normal",
              BS = 99), degs = 4, print.AIC = FALSE, print.BIC = FALSE)

## Not run: 
# Censored data
set.seed(123)
colonsamp <- colon[sample(nrow(colon), 300), ]
CvMcens(Surv(time, status) ~ 1, colonsamp, distr = "normal")

## End(Not run)

Kolmogorov-Smirnov, Cramér-von Mises, and Anderson-Darling tests for complete and right-censored data

Description

Function gofcens computes the Kolmogorov-Smirnov, Cramér-von Mises, and Anderson-Darling statistics ans p-values for complete and right-censored data against eight possible distributions using bootstrapping.

Usage

## Default S3 method:
gofcens(times, cens = rep(1, length(times)),
        distr = c("exponential", "gumbel", "weibull", "normal",
                  "lognormal", "logistic", "loglogistic", "beta"),
        betaLimits = c(0, 1), igumb = c(10, 10), BS = 999,
        params0 = list(shape = NULL, shape2 = NULL, location = NULL,
                       scale = NULL),
        tol = 1e-04, ...)
## S3 method for class 'formula'
gofcens(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

BS

Number of bootstrap samples.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

tol

Precision of survival times.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

...

Additional arguments.

Details

All p-values are calculated via bootstrapping methods. For the three hypothesis tests, the same data generated with the bootstrapping method are used.

The precision of the survival times is important mainly in the data generation step of the bootstrap samples.

When dealing with complete data, we recommend the use of functions ks.test of the stats package and cvm.test and ad.test of the goftest package.

Value

gofcens returns an object of class "gofcens".

An object of class "gofcens" is a list containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the values of the Kolmogovor-Smirnov (KS), Cramér-von Mises (CvM), and Anderson-Darling (AD) test statistics and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

Warning

If the amount of data is large, the execution time of the function can be elevated. The parameter BS can limit the number of random censored samples generated and reduce the execution time.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

J. A. Koziol and S. B. Green. A Cramér-von Mises statistic for randomly censored data. In: Biometrika, 63 (3) (1976), 465-474.

A. N. Pettitt and M. A. Stephens. Modified Cramér-von Mises statistics for censored data. In: Biometrika, 63 (2) (1976), 291-298.

See Also

ks.test (Package stats), cvm.test (Package goftest), and ad.test (Package goftest) for complete data, and KScens for the Kolmogorov-Smirnov test for right-censored data, which returns the p-value.

Examples

## Not run: 
# Complete data
set.seed(123)
gofcens(times = rweibull(100, 12, scale = 4), distr = "weibull", BS = 499)
print(gofcens(times = rweibull(100, 12, scale = 4), distr = "exponential"),
      outp = "table", print.infoBoot = TRUE)

# Censored data
data(colon)
set.seed(123)
colonsamp <- colon[sample(nrow(colon), 300), ]
gofcens(Surv(time, status) ~ 1, colonsamp, distr = "normal")

## End(Not run)

Plot of the Kaplan-Meier and parametric estimations

Description

The kmPlot function generates a plot that combines a Kaplan-Meier survival curve with a parametric survival curve in the same graph. This is useful for comparing non-parametric survival estimates to a fitted parametric survival model.

Usage

## Default S3 method:
kmPlot(times, cens = rep(1, length(times)), distr = "all6",
       colour = c("black", "blue", "cornflowerblue"),
       betaLimits = c(0, 1), igumb = c(10, 10), ggp = FALSE, m = NULL,
       prnt = TRUE, degs = 3, print.AIC = TRUE, print.BIC = TRUE, ...)
## S3 method for class 'formula'
kmPlot(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), the exponential ("exponential") and the beta ("beta") distribution. Default is "all6" and includes the first 6 listed which are the most used distributions.

colour

Vector with three components indicating the colours of the displayed plots. The first element is for the survival curve, the second for the Kaplan-Meier curve, and the last one for the confidence intervals.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

ggp

Logical to use or not the ggplot2 package to draw the plots. Default is FALSE.

m

Optional layout for the plots to be displayed.

prnt

Logical to indicate if the maximum likelihood estimates of the parameters should be printed. Default is TRUE.

degs

Integer indicating the number of decimal places of the numeric results of the output.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

...

Optional arguments for function par, if ggp = FALSE.

Details

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

Value

If prnt = TRUE, the following output is returned:

Distribution

Distribution under study.

Estimates

A list with the maximum likelihood estimates of the parameters of all distributions considered.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

Peterson Jr, Arthur V. Expressing the Kaplan-Meier estimator as a function of empirical subsurvival functions. In: Journal of the American Statistical Association 72.360a (1977): 854-858.

Examples

# Plots for complete data and default distributions
set.seed(123)
x <- rexp(1000, 0.1)
kmPlot(x)

# Plots for censored data using ggplot2
kmPlot(Surv(time, status) ~ 1, colon, distr= "lognormal", ggp = TRUE)

# Plots for censored data from three distributions
data(nba)
kmPlot(Surv(survtime, cens) ~ 1, nba, distr = c("normal", "weibull", "lognormal"),
       prnt = FALSE)

Kolmogorov-Smirnov test for complete and right-censored data

Description

Function KScens computes the Kolmogorov-Smirnov statistic and p-value for complete and right-censored data against eight possible distributions using either bootstrapping or a modified test.

Usage

## Default S3 method:
KScens(times, cens = rep(1, length(times)),
       distr = c("exponential", "gumbel", "weibull", "normal",
                 "lognormal", "logistic", "loglogistic", "beta"),
       betaLimits = c(0, 1), igumb = c(10, 10), BS = 999,
       params0 = list(shape = NULL, shape2 = NULL, location = NULL,
                      scale = NULL),
       tol = 1e-04, boot = TRUE, ...)
## S3 method for class 'formula'
KScens(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

BS

Number of bootstrap samples.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

tol

Precision of survival times.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

boot

Logical to indicate if the p-value is computed using bootstrapping or using the the modified Kolmogorov-Smirnov test (see details). Default is TRUE.

...

Additional arguments.

Details

By default, the p-value is computed via bootstrapping methods.

The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

To avoid long computation times due to bootstrapping, an alternative with complete data is the function ks.test of the stats package.

The precision of the survival times is important mainly in the data generation step of the bootstrap samples.

If boot = FALSE a modified test is used to compute the p-value. Fleming et al. (1980) proposed a modified Kolmogorov-Smirnov test to use with right-censored data. This function reproduces this test for a given survival data and a theorical distribution. The approximation for the p-value is acceptable when it is smaller than 0.8 and excellent when it is smaller than 0.2. The output of the function follows the notation of Fleming et al. (1980).

In presence of ties, different authors provide slightly different definitions of F^n(t)\widehat{F}_n(t), with which other values of the test statistic might be obtained.

Value

KScens returns an object of class "KScens".

An object of class "KScens" is a list containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the modified Kolmogorov-Smirnov statistic (A) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used. If the modified test is used, a 0 is returned.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

T. R. Fleming et al. Modified Kolmogorov-Smirnov test procedure with application to arbitrarily right-censored data. In: Biometrics 36 (1980), 607-625.

See Also

Function ks.test (Package stats) for complete data and gofcens for statistics and p-value of Kolmogorov-Smirnov, Cramér von-Mises and Anderson-Darling together for right-censored data.

Examples

# Censored data with bootstrapping
KScens(Surv(time, status) ~ 1, colon, distr = "norm", BS = 99)

# Censored data using the modified test
KScens(Surv(time, status) ~ 1, colon, distr = "norm", boot = FALSE)

data(nba)
print(KScens(Surv(survtime, cens) ~ 1, nba, "logis", boot = FALSE), degs = 2)
KScens(Surv(survtime, cens) ~ 1, nba, "beta", betaLimits = c(0, 80),
       boot = FALSE)

Survival times of former NBA players.

Description

Survival times of former NBA players after their NBA career.

Usage

data("nba")

Format

A data frame with 3962 observations on the following 3 variables.

id

Player ID

survtime

Time (in years) from end of NBA career until either death or July 31, 2019.

cens

Death indicator (1, exact survival time; 0, right-censored survival time).

Details

The survival times of former NBA players were analyzed by Martínez et al. (2022).

Source

J. A. Martínez, K. Langohr, J. Felipo, L. Consuegra and M. Casals. Data set on mortality of national basketball association (NBA) players. In: Data in Brief, 45 (2022).

Examples

data(nba)
cumhazPlot(Surv(survtime, cens) ~ 1, nba)

Printing method for ADcens object.

Description

Printing method for ADcens object.

Usage

## S3 method for class 'ADcens'
print(x, prnt = TRUE, outp = c("list", "table"),  degs = 3, print.AIC = TRUE,
      print.BIC = TRUE, print.infoBoot = FALSE, ...)

Arguments

x

An object of class ADcens.

prnt

Logical to indicate if the estimations of the Anderson-Darling statistic and p-value should be printed. Default is TRUE.

outp

Indicator of how the output will be displayed. The possible formats are list and table.

degs

Integer indicating the number of decimal places of the numeric results of the output.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

print.infoBoot

Logical to indicate if the number of bootstrap samples used should be printed. Default is FALSE

...

Additional arguments.

Value

If prnt = TRUE, a list or table (if outp = "table") containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the Anderson-Darling statistic (AD) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

The list is also returned invisibly.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

# List output
set.seed(123)
ADcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
       BS = 149)

# Table output
set.seed(123)
print(ADcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
             BS = 99), outp = "table")

Printing method for chisqcens object.

Description

Printing method for chisqcens object.

Usage

## S3 method for class 'chisqcens'
print(x, prnt = TRUE, outp = c("list", "table"),  degs = 3, print.AIC = TRUE,
      print.BIC = TRUE, print.infoBoot = FALSE, ...)

Arguments

x

An object of class chisqcens.

prnt

Logical to indicate if the estimations of the chi-squared statistic and p-value should be printed. Default is TRUE.

outp

Indicator of how the output will be displayed. The possible formats are list and table.

degs

Integer indicating the number of decimal places of the numeric results of the output.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

print.infoBoot

Logical to indicate if the number of bootstrap samples used should be printed. Default is FALSE

...

Additional arguments.

Value

If prnt = TRUE, a list or table (if outp = "table") containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the test statistic (Statistic) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

CellNumber

Vector with two values: the original cell number introduced by the user and the final cell number used.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

The list is also returned invisibly.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

# List output
set.seed(123)
chisqcens(times = rweibull(100, 12, scale = 4), M = 8, distr = "weibull",
          BS = 149)

# Table output
set.seed(123)
print(chisqcens(times = rweibull(100, 12, scale = 4), M = 8, distr = "weibull",
                BS = 99), outp = "table")

Printing method for CvMcens object.

Description

Printing method for CvMcens object.

Usage

## S3 method for class 'CvMcens'
print(x, prnt = TRUE, outp = c("list", "table"),  degs = 3, print.AIC = TRUE,
      print.BIC = TRUE, print.infoBoot = FALSE, ...)

Arguments

x

An object of class CvMcens.

prnt

Logical to indicate if the estimations of the Cramér-von Mises statistic and p-value should be printed. Default is TRUE.

outp

Indicator of how the output will be displayed. The possible formats are list and table.

degs

Integer indicating the number of decimal places of the numeric results of the output.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

print.infoBoot

Logical to indicate if the number of bootstrap samples used should be printed. Default is FALSE

...

Additional arguments.

Value

If prnt = TRUE, a list or table (if outp = "table") containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the Cramér-von Mises statistic (CvM) and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

The list is also returned invisibly.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

# List output
set.seed(123)
CvMcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
        BS = 149)

# Table output
set.seed(123)
print(CvMcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
              BS = 99), outp = "table")

Printing method for gofcens object.

Description

Printing method for gofcens object.

Usage

## S3 method for class 'gofcens'
print(x, prnt = TRUE, outp = c("list", "table"),  degs = 3, print.AIC = TRUE,
      print.BIC = TRUE, print.infoBoot = FALSE,  ...)

Arguments

x

An object of class gofcens.

prnt

Logical to indicate if the values of the Kolmogovor-Smirnov, Cramér-von Mises, and Anderson-Darling test statistics along with the p-values should be printed. Default is TRUE.

outp

Indicator of how the output will be displayed. The possible formats are list and table.

degs

Integer indicating the number of decimal places of the numeric results of the output.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

print.infoBoot

Logical to indicate if the number of bootstrap samples used should be printed. Default is FALSE

...

Additional arguments.

Value

If prnt = TRUE, a list or table (if outp = "table") containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the values of the Kolmogovor-Smirnov (KS), Cramér-von Mises (CvM), and Anderson-Darling (AD) test statistics and the estimated p-value (p-value).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used.

The list is also returned invisibly.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

## Not run: 
# List output
set.seed(123)
gofcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
        BS = 149)

# Table output
set.seed(123)
print(gofcens(times = rweibull(100, 12, scale = 4), distr = "weibull",
              BS = 149), outp = "table")

## End(Not run)

Printing method for KScens object.

Description

Printing method for KScens object.

Usage

## S3 method for class 'KScens'
print(x, prnt = TRUE, outp = c("list", "table"),  degs = 3, print.AIC = TRUE,
      print.BIC = TRUE, print.infoBoot = FALSE, ...)

Arguments

x

An object of class KScens.

prnt

Logical to indicate if the estimations of the Kolmogorov-Smirnov statistic and p-value should be printed. Default is TRUE.

outp

Indicator of how the output will be displayed. The possible formats are list and table.

degs

Integer indicating the number of decimal places of the numeric results of the output.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

print.infoBoot

Logical to indicate if the number of bootstrap samples used should be printed. Default is FALSE

...

Additional arguments.

Value

If prnt = TRUE, a list or table (if outp = "table") containing the following components:

Distribution

Null distribution.

Hypothesis

Parameters under the null hypothesis (if params0 is provided).

Test

Vector containing the value of the modified Kolmogorov-Smirnov statistic (A), the estimated p-value (p-value), the estimation of the image of the last recorded time (F(y_m)) and the last recorded time (y_m).

Estimates

Vector with the maximum likelihood estimates of the parameters of the distribution under study.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

BS

The number of bootstrap samples used. If the modified test is used, a 0 is returned.

The list is also returned invisibly.

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

Examples

# List output
set.seed(123)
KScens(times = rweibull(100, 12, scale = 4), distr = "weibull", BS = 99)

# Table output
set.seed(123)
print(KScens(times = rweibull(100, 12, scale = 4), distr = "weibull", BS = 99),
      outp = "table")

Probability plots to check the goodness of fit of parametric models

Description

probPlot provides four types of probability plots: P-P plot, Q-Q plot, Stabilised probability plot, and Empirically Rescaled plot to check if a certain distribution is an appropiate choice for the data.

Usage

## Default S3 method:
probPlot(times, cens = rep(1, length(times)),
         distr = c("exponential", "gumbel", "weibull", "normal",
                   "lognormal", "logistic", "loglogistic", "beta"),
         plots = c("PP", "QQ", "SP", "ER"),
         colour = c("green4", "deepskyblue4", "yellow3",
                    "mediumvioletred"), mtitle = TRUE, ggp = FALSE,
         m = NULL, betaLimits = c(0, 1), igumb = c(10, 10),
         prnt = TRUE, degs = 3,
         params0 = list(shape = NULL, shape2 = NULL,
                        location = NULL, scale = NULL), print.AIC = TRUE,
                        print.BIC = TRUE, ...)
## S3 method for class 'formula'
probPlot(formula, data, ...)

Arguments

times

Numeric vector of times until the event of interest.

cens

Status indicator (1, exact time; 0, right-censored time). If not provided, all times are assumed to be exact.

distr

A string specifying the name of the distribution to be studied. The possible distributions are the exponential ("exponential"), the Weibull ("weibull"), the Gumbel ("gumbel"), the normal ("normal"), the lognormal ("lognormal"), the logistic ("logistic"), the loglogistic ("loglogistic"), and the beta ("beta") distribution.

plots

Vector stating the plots to be displayed. Possible choices are the P-P plot ("PP"), the Q-Q plot ("QQ"), the Stabilised Probability plot ("SP"), and the Empirically Rescaled plot ("ER"). By default, all four plots are displayed.

colour

Vector indicating the colours of the displayed plots. The vector will be recycled if its length is smaller than the number of plots to be displayed.

mtitle

Logical to add or not the title "Probability plots for a distr distribution" to the plot. Default is TRUE.

ggp

Logical to use or not the ggplot2 package to draw the plots. Default is FALSE.

m

Optional layout for the plots to be displayed.

betaLimits

Two-components vector with the lower and upper bounds of the Beta distribution. This argument is only required, if the beta distribution is considered.

igumb

Two-components vector with the initial values for the estimation of the Gumbel distribution parameters.

prnt

Logical to indicate if the maximum likelihood estimates of the parameters should be printed. Default is TRUE.

degs

Integer indicating the number of decimal places of the numeric results of the output.

params0

List specifying the parameters of the theoretical distribution. By default, parameters are set to NULL and estimated with the maximum likelihood method. This argument is only considered, if all parameters of the studied distribution are specified.

formula

A formula with a numeric vector as response (which assumes no censoring) or Surv object.

data

Data frame for variables in formula.

print.AIC

Logical to indicate if the AIC of the model should be printed. Default is TRUE

print.BIC

Logical to indicate if the BIC of the model should be printed. Default is TRUE

...

Optional arguments for function par, if ggp = FALSE.

Details

By default, function probPlot draws four plots: P-P plot, SP plot, Q-Q plot, and EP plot. Following, a description is given for each plot.

The Probability-Probability plot (P-P plot) depicts the empirical distribution, F^(t)\widehat{F}(t), which is obtained with the Kaplan-Meier estimator if data are right-censored, versus the theoretical cumulative distribution function (cdf), F0^(t)\widehat{F_0}(t). If the data come from the chosen distribution, the points of the resulting graph are expected to lie on the identity line.

The Stabilised Probability plot (SP plot), proposed by Michael (1983), is a transformation of the P-P plot. It stabilises the variance of the plotted points. If F0=FF_0 = F and the parameters of F0F_0 are known, F0^(t)\widehat{F_0}(t) corresponds to the cdf of a uniform order statistic, and the arcsin transformation stabilises its variance. If the data come from distribution F0F_0, the SP plot will resemble the identity line.

The Quartile-Quartile plot (Q-Q plot) is similar to the P-P plot, but it represents the sample quantiles versus the theoretical ones, that is, it plots tt versus F^01(F^(t))\widehat{F}_0^{-1}(\widehat{F}(t)). Hence, if F0F_0 fits the data well, the resulting plot will resemble the identity line.

A drawback of the Q-Q plot is that the plotted points are not evenly spread. Waller and Turnbull (1992) proposed the Empirically Rescaled plot (EP plot), which plots F^u(t)\widehat{F}_u(t) against F^u(F^01(F^(t)))\widehat{F}_u(\widehat{F}_0^{-1}(\widehat{F}(t))), where F^u(t)\widehat{F}_u(t) is the empirical cdf of the points corresponding to the uncensored observations. Again, if F^0\widehat{F}_0 fits the data well, the ER plot will resemble the identity line.

By default, all four probability plots are drawn and the maximum likelihood estimates of the parameters of the chosen parametric model are returned. The parameter estimation is acomplished with the fitdistcens function of the fitdistrplus package.

Value

If prnt = TRUE, the following output is returned:

Distribution

Distribution under study.

Parameters

Parameters used to draw the plots (if params0 is provided).

Estimates

A list with the maximum likelihood estimates of the parameters of all distributions considered.

StdErrors

Vector containing the estimated standard errors.

aic

The Akaike information criterion.

bic

The so-called BIC or SBC (Schwarz Bayesian criterion).

Author(s)

K. Langohr, M. Besalú, M. Francisco, A. Garcia, G. Gómez.

References

J. R. Michael. The Stabilized Probability Plot. In: Biometrika 70 (1) (1983), 11-17.

L.A. Waller and B.W. Turnbull. Probability Plotting with Censored Data. In: American Statistician 46 (1) (1992), 5-12.

Examples

# P-P, Q-Q, SP, and EP plots for complete data
set.seed(123)
x <- rlnorm(1000, 3, 2)
probPlot(x)
probPlot(x, distr = "lognormal")

# P-P, Q-Q, SP, and EP plots for censored data using ggplot2
probPlot(Surv(time, status) ~ 1, colon, "weibull", ggp = TRUE)

# P-P, Q-Q and SP plots for censored data and lognormal distribution
data(nba)
probPlot(Surv(survtime, cens) ~ 1, nba, "lognorm", plots = c("PP", "QQ", "SP"),
         ggp = TRUE, m = matrix(1:3, nr = 1))