library(GenTwoArmsTrialSize)

Examples

Example 1. Sample Size for two arms continuous end point clinical trial with noncompliance and expected loss of follow-up

getSizeMean(design="parallel", test="equivalence", alpha=0.05, 
            beta=0.20, sigma=0.10, k=1, delta=0.05, TTE=0.01, 
            rho=c(0.05, 0.07), r=0.1)
#>      n_trt n_ctl
#> Size   113   113

Example 2. Sample Size for two arms binary end point clinial trial with noncompliance and expected loss of follow-up

getSizeProp(design="crossover", test="superiority", alpha=0.05,
            beta=0.20, varsigma=c(0.5, 0.5), k=1, seqnumber=2,
            delta=0.10, TTE=0, rho=c(0.05, 0.07), r=0.1)
#>      n_trt n_ctl
#> Size    86    86

Example 3. Sample Size for two arms time to event point clinial trial with noncompliance and expected loss of follow-up

getSizeTTE(design="parallel", test="equality", alpha=0.05, beta=0.20,
           varlambda=c(1,2), k=1, ttotal=3, taccrual=1, 
           gamma=0.00001, delta=1, rho=c(0.05, 0.07), r=0.1)
#> [1] 1.192941
#> [1] 3.759987
#>      n_trt n_ctl
#> Size    56    56

Example 4: Sample Size for two arms ordinal point clinial trial with noncompliance and expected loss of follow-up

getSizeOrd(design="parallel", test="equality", alpha=0.05, beta=0.10,
           varcatprob= list(c(0.2,0.5,0.2,0.1),
                            c(0.378,0.472,0.106,0.044)), 
           k=1, theta=0.877, delta=0, rho=c(0.05, 0.07), r=0.1)
#>      n_trt n_ctl
#> Size   138   138

References

Chow, Shein-Chung, Jun Shao, Hansheng Wang, and Yuliya Lokhnygina. 2018. Sample Size Calculations in Clinical Research. Third edition. Chapman & Hall/CRC Biostatistics Series. CRC Press, Taylor & Francis Group.

Julious, Steven A. 2023. Sample Sizes for Clinical Trials. Second edition. CRC Press.

Lachin, John M., and Mary A. Foulkes. 1986. “Evaluation of Sample Size and Power for Analyses of Survival with Allowance for Nonuniform Patient Entry, Losses to Follow-up, Noncompliance, and Stratification.” Biometrics (Malden, MA) 42 (3): 507–19.

Sato, Tosiya. 2000. “Sample Size Calculations with Compliance Information.” Statistics in Medicine (Chichester, UK) 19 (19): 2689–97.

Whitehead, John. 1993. “Sample Size Calculations for Ordered Categorical Data.” Statistics in Medicine (Chichester) 12 (24): 2257–71.

Wittes, Janet. 2002. “Sample Size Calculations for Randomized Controlled Trials.” Epidemiologic Reviews (United States) 24 (1): 39–53.

- Examples
- References