Package: GSSE
Type: Package
Title: Genotype-Specific Survival Estimation
Description: We propose a fully efficient sieve maximum likelihood
        method to estimate genotype-specific distribution of
        time-to-event outcomes under a nonparametric model. We can
        handle missing genotypes in pedigrees.  We estimate the
        time-dependent hazard ratio between two genetic mutation groups
        using B-splines, while applying nonparametric maximum
        likelihood estimation to the reference baseline hazard
        function.  The estimators are calculated via an
        expectation-maximization algorithm.
Version: 0.1
Date: 2015-10-17
Author: Baosheng Liang, Yuanjia Wang and Donglin Zeng
Maintainer: Baosheng Liang <liangbsunc@gmail.com>
Depends: R(>= 3.0.1)
Suggests: MASS
Imports: Iso (>= 0.0-17), splines, stats, zoo (>= 1.7-12)
License: GPL (>= 2)
LazyLoad: yes
NeedsCompilation: no
Packaged: 2026-07-03 11:03:46 UTC; root
Repository: https://cran.r-universe.dev
Date/Publication: 2015-10-20 08:06:35 UTC
RemoteUrl: https://github.com/cran/GSSE
RemoteRef: HEAD
RemoteSha: 93e106f7a2d21dc9d0dbf88af17a10aa85509ae4