Package: GEVACO
Type: Package
Title: Joint Test of Gene and GxE Interactions via Varying Coefficients
Version: 1.0.1
Author: Zhengyang Zhou [aut] Sydney Manning [aut, cre] Chao Xing [aut]
        Hung-Chih Ku [aut]
Depends: R (>= 3.6)
Description: A novel statistical model to detect the joint genetic and
        dynamic gene-environment (GxE) interaction with continuous
        traits in genetic association studies. It uses
        varying-coefficient models to account for different GxE
        trajectories, regardless whether the relationship is linear or
        not. The package includes one function, GxEtest(), to test a
        single genetic variant (e.g., a single nucleotide polymorphism
        or SNP), and another function, GxEscreen(), to test for a set
        of genetic variants. The method involves a likelihood ratio
        test described in Crainiceanu, C. M., and Ruppert, D. (2004)
        <doi:10.1111/j.1467-9868.2004.00438.x>.
License: GPL-3
Encoding: UTF-8
LazyData: true
Imports: nlme, RLRsim, stats
Suggests: rmarkdown, knitr
RoxygenNote: 7.1.2
VignetteBuilder: knitr
Maintainer: Sydney Manning <sydney.manning@unthsc.edu>
NeedsCompilation: no
Packaged: 2026-06-23 08:13:34 UTC; root
Repository: https://cran.r-universe.dev
Date/Publication: 2021-12-10 11:10:05 UTC
RemoteUrl: https://github.com/cran/GEVACO
RemoteRef: HEAD
RemoteSha: dc0079dfbd67e5a3f9d2f8ead168962089935fce