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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "FracFixR" in publications use:'
type: software
license: CC-BY-4.0
title: 'FracFixR: Compositional Statistical Framework for RNA Fractionation Analysis'
version: 1.1.0
doi: 10.32614/CRAN.package.FracFixR
abstract: A compositional statistical framework for absolute proportion estimation
  between fractions in RNA sequencing data. 'FracFixR' addresses the fundamental challenge
  in fractionated RNA-seq experiments where library preparation and sequencing depth
  obscure the original proportions of RNA fractions. It reconstructs original fraction
  proportions using non-negative linear regression, estimates the "lost" unrecoverable
  fraction, corrects individual transcript frequencies, and performs differential
  proportion testing between conditions. Supports any RNA fractionation protocol including
  polysome profiling, sub-cellular localization, and RNA-protein complex isolation.
authors:
- family-names: Cleynen
  given-names: Alice
  email: alice.cleynen@cnrs.fr
  orcid: https://orcid.org/0000-0001-8083-0204
- family-names: Ravindran
  given-names: Agin
- family-names: Shirokikh
  given-names: Nikolay
  email: nikolay.shirokikh@uwa.edu.au
  orcid: https://orcid.org/0000-0001-8249-358X
repository: https://cran.r-universe.dev
commit: d77c96c6362c3c75d0a9c0d67580f42ac21e14c7
date-released: '2026-05-11'
contact:
- family-names: Cleynen
  given-names: Alice
  email: alice.cleynen@cnrs.fr
  orcid: https://orcid.org/0000-0001-8083-0204