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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "CFO" in publications use:'
type: software
license: GPL-2.0-only
title: 'CFO: CFO-Type Designs in Phase I/II Clinical Trials'
version: 2.0.0
doi: 10.32614/CRAN.package.CFO
abstract: In phase I clinical trials, the primary objective is to ascertain the maximum
  tolerated dose (MTD) corresponding to a specified target toxicity rate. The subsequent
  phase II trials are designed to examine the potential efficacy of the drug based
  on the MTD obtained from the phase I trials, with the aim of identifying the optimal
  biological dose (OBD). The 'CFO' package facilitates the implementation of dose-finding
  trials by utilizing calibration-free odds type (CFO-type) designs. Specifically,
  it encompasses the calibration-free odds (CFO) (Jin and Yin (2022) <https://doi.org/10.1177/09622802221079353>),
  two-dimensional CFO (2dCFO) (Wang et al. (2023) <https://doi.org/10.3389/fonc.2023.1294258>),
  time-to-event CFO (TITE-CFO) (Jin and Yin (2023) <https://doi.org/10.1002/pst.2304>),
  fractional CFO (fCFO), accumulative CFO (aCFO), TITE-aCFO, and f-aCFO designs (Fang
  and Yin (2024) <https://doi.org/ 10.1002/sim.10127>). It supports phase I/II trials
  for the CFO design and only phase I trials for the other CFO-type designs. The ‘CFO'
  package accommodates diverse CFO-type designs, allowing users to tailor the approach
  based on factors such as dose information inclusion, handling of late-onset toxicity,
  and the nature of the target drug (single-drug or drug-combination). The functionalities
  embedded in 'CFO' package include the determination of the dose level for the next
  cohort, the selection of the MTD for a real trial, and the execution of single or
  multiple simulations to obtain operating characteristics. Moreover, these functions
  are equipped with early stopping and dose elimination rules to address safety considerations.
  Users have the flexibility to choose different distributions, thresholds, and cohort
  sizes among others for their specific needs. The output of the 'CFO' package can
  be summary statistics as well as various plots for better visualization.
authors:
- family-names: Fang
  given-names: Jialu
  email: u3008682@connect.hku.hk
- family-names: Wang
  given-names: Wenliang
  email: wangwl@connect.hku.hk
- family-names: Zhang
  given-names: Ninghao
  email: zhangnh421@connect.hku.hk
- family-names: Yin
  given-names: Guosheng
  email: gyin@hku.hk
repository: https://CRAN.R-project.org/package=CFO
date-released: '2024-09-10'
contact:
- family-names: Fang
  given-names: Jialu
  email: u3008682@connect.hku.hk