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cff-version: 1.2.0
message: 'To cite package "BIGL" in publications use:'
type: software
license: GPL-3.0-only
title: 'BIGL: Biochemically Intuitive Generalized Loewe Model'
version: 1.9.3
doi: 10.32614/CRAN.package.BIGL
abstract: 'Response surface methods for drug synergy analysis. Available methods include
  generalized and classical Loewe formulations as well as Highest Single Agent methodology.
  Response surfaces can be plotted in an interactive 3-D plot and formal statistical
  tests for presence of synergistic effects are available. Implemented methods and
  tests are described in the article "BIGL: Biochemically Intuitive Generalized Loewe
  null model for prediction of the expected combined effect compatible with partial
  agonism and antagonism" by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas,
  Olivier Thas, Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
  <https://doi.org/10.1038/s41598-017-18068-5>.'
authors:
- family-names: Turner
  given-names: Heather
- family-names: Tourny
  given-names: Annelies
- family-names: Thas
  given-names: Olivier
- family-names: Nazarov
  given-names: Maxim
- family-names: Bagdziunas
  given-names: Rytis
- family-names: Hawinkel
  given-names: Stijn
- family-names: Pérez
  given-names: Javier Franco
- family-names: Mutambanengwe
  given-names: Kathy
  email: kathy.mutambanengwe@openanalytics.eu
repository: https://CRAN.R-project.org/package=BIGL
repository-code: https://github.com/openanalytics/BIGL
url: https://github.com/openanalytics/BIGL
date-released: '2024-07-31'
contact:
- family-names: Mutambanengwe
  given-names: Kathy
  email: kathy.mutambanengwe@openanalytics.eu