Package: BElikelihood Type: Package Title: Likelihood Method for Evaluating Bioequivalence Version: 1.1 Date: 2024-02-29 Maintainer: Liping Du Authors@R: c(person("Liping", "Du", role = c("aut", "cre"), email = "liping.du@vumc.org", comment=c(ORCID = "0000-0003-4926-2135")), person("Leena", "Choi", role = "aut", email = "naturechoi@gmail.com", comment = c(ORCID = "0000-0002-2544-7090")), person("Cole", "Beck", role = "aut", email = "cole.beck@vumc.org", comment = c(ORCID = "0000-0002-6849-6255"))) Description: A likelihood method is implemented to present evidence for evaluating bioequivalence (BE). The functions use bioequivalence data [area under the blood concentration-time curve (AUC) and peak concentration (Cmax)] from various crossover designs commonly used in BE studies including a fully replicated, a partially replicated design, and a conventional 2x2 crossover design. They will calculate the profile likelihoods for the mean difference, total standard deviation ratio, and within subject standard deviation ratio for a test and a reference drug. A plot of a standardized profile likelihood can be generated along with the maximum likelihood estimate and likelihood intervals, which present evidence for bioequivalence. See Liping Du and Leena Choi (2015) . License: GPL (>= 3) Imports: ggplot2, mvtnorm Suggests: knitr, nlme, rmarkdown RoxygenNote: 7.3.1 Depends: R (>= 3.5.0) VignetteBuilder: knitr NeedsCompilation: no Packaged: 2026-06-21 11:18:30 UTC; root Author: Liping Du [aut, cre] (), Leena Choi [aut] (), Cole Beck [aut] () Repository: https://cran.r-universe.dev Date/Publication: 2024-03-06 02:29:02 UTC RemoteUrl: https://github.com/cran/BElikelihood RemoteRef: HEAD RemoteSha: 83134c519ed331d1330befb2fd6e83f75c0e5ec3