NEWS
AllelicSeries 1.0.0
- Added ability to run COAST starting from summary statistics:
ASBTSS
runs the allelic series burden test from summary statistics.
ASKATSS
runs the allelic series SKAT test from summary statistics.
COASTSS
runs the omnibus coding-variant allelic series test from summary statistics.
- Added a
CalcSumstats
function to generate summary statistics from individual-level data.
AllelicSeries 0.6.0
- Replaced the
CountAlleles
function with a similar (but faster) Counts
function that returns counts the total number of alleles, variants, and carriers by variant class.
- Updated the formatting of the results output by the main
COAST
function.
AllelicSeries 0.5.0
- Added option (
min_mac
) to filter the variant set to only include those variants having at least a minimum minor allele count (10 is recommended).
- Added a function (
CountAlleles
) to count the number of alleles of each variant category present in the genotype matrix. Also allows for counting the number of carriers of each type of allele.
- By default,
COAST
now reports the number of alleles of each variant category that contributed to the test.